DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	512	Identity:	126/512 - (24%)
Similarity:	228/512 - (44%)	Gaps:	81/512 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIVLCAFLALPLFLVT-----YFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFG 61
            |:::...|.|.....|     :.:||:          .||:.||.:|.          ||....|
Human    12 WVLVATSLVLLYIYGTHSHKLFKKLGI----------PGPTPLPFLGT----------ILFYLRG 56

  Fly    62 WWHEYGKDNFRY---WIGYYSN----IMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTS 119
            .|:...:.|.:|   | |.|..    :::.:|..::.:|..:..    .|:....|...:|.|.|
Human    57 LWNFDRECNEKYGEMW-GLYEGQQPMLVIMDPDMIKTVLVKECY----SVFTNQMPLGPMGFLKS 116

  Fly   120 TGS-----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTL 179
            ..|     :|.:.|.:::|||.....::...::::.....:..|::.|:.....:.::.....|:
Human   117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTM 181

  Fly   180 DVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTL--K 241
            |||..|..||:::::.|.....::..|.:   :|:....|:.....||.| .|.:...:..|  |
Human   182 DVITGTLFGVNLDSLNNPQDPFLKNMKKL---LKLDFLDPFLLLISLFPFLTPVFEALNIGLFPK 243

  Fly   242 TLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-----VDGRPLTSQELYEEV 301
            .:..|....|.:..|.|         ..:..:.::.|...::.|:     ...:.|:..||..:.
Human   244 DVTHFLKNSIERMKESR---------LKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299

  Fly   302 STFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDA--TFQEISTMKHLDLF 364
            ...:|..:|||::.:.|.:|.|:.|||.|:|| .|:.|.:    |...|  |:..:..|::||:.
Human   300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKL-QEEIDAV----LPNKAPVTYDALVQMEYLDMV 359

  Fly   365 IKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPE-RFDREK 428
            :.|..||:|.|..:.|..:||..|:|..:|||..:.:.:..|.::.:.:.:|.||.|| ||.::.
Human   360 VNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKN 424

  Fly   429 PGP---FEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPA--------LDEL 474
            ...   :.|:||.||||||||.:|||..||..|.:.::||...|.        ||.|
Human   425 KDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	116/460 (25%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	120/475 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810