DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	517	Identity:	160/517 - (30%)
Similarity:	260/517 - (50%)	Gaps:	60/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RRKRMLNKF-QGPSMLPLVGNAHQMGNTPTE----ILNRFFGWWHEYGKDNFRYWIG-YYSNIMV 83
            |..|.|:.| |.|....|:|:...:  ||||    .|.|..|.:.:    .|..||| ....|.:
Mouse    43 RNYRHLHGFPQPPKRNWLMGHVGMV--TPTEQGLKELTRLVGTYPQ----GFLMWIGPMVPVITL 101

  Fly    84 TNPKYMEFILSSQTLISKSDV--YDLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEV 146
            .:...:..||::...::..||  |.:..||||.|||.|.|.||.:||:|:|||||||||:.:.::
Mouse   102 CHSDIVRSILNASAAVALKDVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKI 166

  Fly   147 MNENSTKFIDQLKK-VADGGNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITY 210
            .|:::.....:.:: ::||....|..|....:|||.:.........|..| :||..:.|..:::.
Mouse   167 FNDSTNIMHAKWQRLISDGSARLDMFEHVSLMTLDSLQKCVFSFDSNCQE-KSSEYIAAILELSA 230

  Fly   211 TIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIE-VRKSGLEVGIKADEFSRK 274
            .:..|...|......|::..|:...:.|....:.:||:.:|.:|.. :...||:..:|:...| |
Mouse   231 LVAKRHQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKS-K 294

  Fly   275 KMAFLDTLLSSK-VDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQC 338
            .:.|:|.||.|| .||:.|:.:::..|..||||||||||.||:.:.:|.|:|||:.||:...|..
Mouse   295 TLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQ 359

  Fly   339 DVMGASGLGR---DATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTL 399
            :::    .||   :..:.:::.:..|.:.|||:.||:|.|..|.|...:|.:: ||..:|||...
Mouse   360 ELL----RGREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPKGIIC 420

  Fly   400 NLGLLMLGYNDRVFKDPHKFQPERFDREK---PGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKI 461
            .:.:..:.:|..|:.||..:.|.|||.|.   ..|..::||||||||||||.||:.|:|..::..
Mouse   421 LISIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALT 485

  Fly   462 IRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMK 523
            :..|.:||  |:                            .:|.....:.|::|.||.||::
Mouse   486 LLRFRLLP--DD----------------------------KEPRRQPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	146/451 (32%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	152/500 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650