Protein Alignment Cyp4e1 and Cyp3a57

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001093650.1
• Gene: Cyp3a57 / 622127
• MGIID: 3646373
• Length: 503
• Species: Mus musculus
• Alignment Length: 515
• Identity: 136/515 - (26%)
• Similarity: 243/515 - (47%)
• Gaps: 72/515 - (13%)

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW--- 63
            |::|...|.......||.. ||.::..:    .||..|||.||          |:|...|.|
Mouse    12 WVLLVTSLVFFYIYGTYSH-GLFKKLGI----PGPKPLPLFGN----------IINYLDGMWKFD 61

  Fly    64 ----HEYGKDNFRYWIGYYSN----IMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLL--- 117
                .:|||    .| |:|..    :.:.:|:.::.:|..:..    .|:....|:..:|.|
Mouse    62 DDCYKKYGK----IW-GFYEGPQPILAIMDPEIIKIVLVKECY----SVFTNRRPFGPVGFLKKS 117

  Fly   118 --TSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLD 180
              .|...:|.:.|.:::|.|..:.|::...:|.:.....:..|::..:.....:.::.....::|
Mouse   118 ITISEDEEWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPINMKDIFGAYSMD 182

  Fly   181 VICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTL--KT 242
            ||..|:.||:|:::.|.....||..|.|   :|.:.|.|:..:..||.| .|.|...:.::  :.
Mouse   183 VITGTSCGVNIDSLNNPQDPFVQKIKKI---LKFKFFDPFLLSVVLFPFLTPIYEMLNLSIFPRQ 244

  Fly   243 LQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDG-----RPLTSQELYEEVS 302
            ..:|..:.:.|   ::|..|      |...:.::.||..:::::...     :.|:..|:..:..
Mouse   245 SMNFFKKFVKK---MKKDRL------DYNQKNRVDFLQLMMNTQNSKGQESLKALSDLEMAAQTL 300

  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367
            .|:|.|:|.|::.:.|.:|.|:.|||.|:||   |.::..|.......|:..:..|::||:.:.|
Mouse   301 IFIFGGYDGTSTSISFIMYELATHPDVQKKL---QDEIDRALPNKAPVTYDALMDMEYLDMVVNE 362

  Fly   368 AQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG-- 430
            :.||||.|..|.||::||..|.|..:||||.:.:.:..|..:...:.:|..|.||||.:|..|
Mouse   363 SLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNI 427

  Fly   431 -PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQP 489
             |:.|:||..|||||||.:|||:.:|..|:.:::||.|.|.      ::..|...:..||
Mouse   428 DPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPC------EETQIPVKISRQP 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	116/442 (26%)
Cyp3a57	NP_001093650.1	cytochrome_P450	67..492	CDD:477761	118/445 (27%)