Protein Alignment Cyp4e1 and cyp46a1.3

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001027517.1
• Gene: cyp46a1.3 / 613109
• XenbaseID: XB-GENE-969052
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 501
• Identity: 130/501 - (25%)
• Similarity: 230/501 - (45%)
• Gaps: 73/501 - (14%)

  Fly     1 MWIVL--CAFLALPLFLVTYFEL-GLLRRKRM-LNKFQGPSMLPLVGNAHQMGNTPTEI------ 55
            :|.::  .|.|.|.|.|:.:... |.:....| .:...||..     ::..:|::||.:
 Frog     3 LWALIGWAALLLLALILICFLLFSGYIHYIHMKYDHIPGPPR-----DSFFLGHSPTMLRLMKNN 62

  Fly    56 ---LNRFFGWWHEYG---KDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTH----- 109
               .:.|.||..:||   :.|..:.:    .|:|.:|:.::.:|.|.. .||...||:..
 Frog    63 LLMYDHFLGWVQKYGPVVRINGLHRV----IILVVSPEAVKELLMSPK-YSKDKFYDVIANMFGV 122

  Fly   110 PWLGLGLLTSTG-SKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEE 173
            .::|.||:|... ..|||.|:::.|||....|.......||.:.:.:::|.:.|||.......:.
 Frog   123 RFMGKGLVTDRDYDHWHKQRRIMDPAFSRTYLMGLMGPFNEKAEELMEKLMEKADGKCEIKMHDM 187

  Fly   174 AHYLTLDVICDTAMGVSINAMEN-------RSSSVVQAFKD-----ITYTIKMRAFSPWKRNKYL 226
            ...||||||...|.|:.:|::.:       ..|.|::...:     :.|::..|.|
 Frog   188 LSRLTLDVIGKVAFGMELNSLNDDLTPFPKAISLVMKGIVEMRNPMVRYSLAKRGF--------- 243

  Fly   227 FHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRP 291
                  ..:..::::.|:....|.|.:|.:..:.|.|:.:.          .|..:|........
 Frog   244 ------IRKVQESIRLLRQTGKECIERRQKQIQDGEEIPVD----------ILTQILKGAAMEEE 292

  Fly   292 LTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEIS 356
            ...:.|.:...||...|.:||.:.:.|.|..|.|:|:..||...|..:|:|:.   ||..::::.
 Frog   293 CDPEILLDNFVTFFIAGQETTANQLSFVVMELGRNPEILEKAQAEIDEVIGSK---RDIEYEDLG 354

  Fly   357 TMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQP 421
            .:::|...:||..||||:.|...|...:|.||||..||:..|:.|...::|..::.:.||..|.|
 Frog   355 KLQYLSQVLKETLRLYPTAPGTSRGLTEDMVIDGVKVPENVTIMLNSYIMGRMEQYYSDPLTFNP 419

  Fly   422 ERFDREKPGP-FEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFE 466
            :||..:.|.| :.|.|||.|||:||||.|:.:|.|.|::|:::.:|
 Frog   420 DRFSPDAPKPYYSYFPFSLGPRSCIGQVFSQMEAKVVMAKLLQRYE 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	112/418 (27%)
cyp46a1.3	NP_001027517.1	CYP46A1-like	66..490	CDD:410706	117/433 (27%)