Protein Alignment Cyp4e1 and cyp4v2a

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001071070.1
• Gene: cyp4v2a / 558851
• ZFINID: ZDB-GENE-061103-601
• Length: 513
• Species: Danio rerio
• Alignment Length: 492
• Identity: 188/492 - (38%)
• Similarity: 278/492 - (56%)
• Gaps: 36/492 - (7%)

  Fly     4 VLC-AFLALPLFLVTYFELGLLRRKRMLNKFQG-PSMLPLVGNAHQMGNTPTEILNRFFGWWHEY 66
            |:| |::...| |.:|     |.:.:.|....| .:..|.:|||.|..:.....| :..|:..|:
Zfish    19 VICFAYITYQL-LKSY-----LHKWKELKPIPGIGNTFPFIGNALQFKSNGDFFL-QLVGYTTEF 76

  Fly    67 -GKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGSKWHKHRKM 130
             .....:.|||....:::.:.:.:|.:|::...|.|:..|...|||||.|||||||.||.:.|||
Zfish    77 QNSPLLKIWIGPIPFLILFHAETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRRKM 141

  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGG--NIFDFQEEAHYLT---LDVICDTAMGVS 190
            :||.|||:||.:|.|||||.:...|::|:|.|..|  |.|.      ::|   ||:||:||||..
Zfish   142 LTPTFHFSILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFS------HITLCALDIICETAMGKR 200

  Fly   191 INAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRI 255
            |.|..|..|..|:....::..|..|...||....:::::..|..|::::||.|..||..:|.:|.
Zfish   201 IYAQSNYDSEYVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTESVINERA 265

  Fly   256 EVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-VDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFA 319
            |. .|.:|...::|:..||:.||||.||.:| .||:.||.:::.|||.||||||||||.:.:.:|
Zfish   266 EY-LSYVESDSESDQGMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWA 329

  Fly   320 VYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEK 384
            ::||..||:.|.|...|..:|.|.|  .|....:::..:::|:..|||:.||:|||||..|....
Zfish   330 IHLLGSHPEVQRKAQQELFEVFGES--ERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICD 392

  Fly   385 DYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREK---PGPFEYVPFSAGPRNCIG 446
            |..|:|..|||||.:.:....|..:.|.|.||.:|:||||..|.   ..|:.|:|||||.|||||
Zfish   393 DTQINGFKVPKGTNIVVITYALHRDPRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIG 457

  Fly   447 QKFALLEIKTVVSKIIRNF--------EVLPALDELV 475
            |:||::|.|.:::.|:|.|        |.|..|.|||
Zfish   458 QRFAIMEEKVILAYILRYFNIVACQKREELRPLGELV 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	171/425 (40%)
cyp4v2a	NP_001071070.1	cytochrome_P450	68..503	CDD:477761	173/436 (40%)