DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	157/549 - (28%)
Similarity:	269/549 - (48%)	Gaps:	85/549 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEY 66
            ::.:.:.|.|.|.||...:. .|:|:.:|..||               ..|:...:.|||.....
  Rat    18 FLQVASVLGLLLLLVKAVQF-YLQRQWLLKAFQ---------------QFPSPPFHWFFGHKQFQ 66

  Fly    67 GK----------DNF-----RYWIGYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTHPW 111
            |.          :||     |::.|..:.::|.:|.||:.||      .:||     ||.|..||
  Rat    67 GDKELQQIMTCVENFPSAFPRWFWGSKAYLIVYDPDYMKVIL------GRSDPKANGVYRLLAPW 125

  Fly   112 LGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHY 176
            :|.|||...|..|.:||:|:|||||::||:.:.:.|.::....:|:.:::|...:..:..:....
  Rat   126 IGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLAGQDSSIEIFQHISL 190

  Fly   177 LTLDVI--CDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKT 239
            :|||.:  |..:...|:. ::....|.:||..::......|..:.:.:|..:::|:.....:::.
  Rat   191 MTLDTVMKCAFSHNGSVQ-VDGNYKSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFSSNGHLFNRA 254

  Fly   240 LKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRK-KMAFLDTLLSSKVD-GRPLTSQELYEEVS 302
            .:...|.|:.:    |::||..|:...:.::..:| ::.|||.||.:::: |..|:.::|..||.
  Rat   255 CQLAHDHTDGV----IKLRKDQLQNAGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVD 315

  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367
            ||||||||||.|||.:..|.|:.||:.|::...|...|:|.   |...|:..:..:.:..:.|||
  Rat   316 TFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLGD---GSSITWDHLDQIPYTTMCIKE 377

  Fly   368 AQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP-G 430
            |.||||.||.|.|........ ||..:|||..:.|.:..|.:|.:|:.:|..|.|.||..:.| .
  Rat   378 ALRLYPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRH 442

  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSR 495
            ...::|||.|.|||||::||:.|:|.:|:..:..||:||                  .|.:.
  Rat   443 SHSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLP------------------DPTKV--- 486

  Fly   496 DAHNHKYDPILSASMTLKSENGLHLRMKQ 524
                    ||....:.|||:||::|.:|:
  Rat   487 --------PIPLPRLVLKSKNGIYLYLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	136/460 (30%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	145/493 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750