DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and cyp-25A3

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001040850.1	Gene:	cyp-25A3 / 4363046	WormBaseID:	WBGene00014697	Length:	502	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	150/492 - (30%)
Similarity:	229/492 - (46%)	Gaps:	54/492 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AFLALPLFLVT------YFELGLLRRKRMLNK--FQGPSMLPLVGNAHQMGNTPTEI-LNRFFGW 62
            |||.|...||:      |..|....|.|:..|  ..||....|:||..|:.....:: .:..:.|
Worm     2 AFLILTSILVSLVSFIIYVILARKERFRLRGKIGLSGPEPHWLMGNLKQIIERKAKLGYDDSYDW 66

  Fly    63 WHEYGK---DNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHP------WLGLGLLT 118
            :::..|   :.|..:.|...||.:||.:.::.:.    :.:.|:..|.|.|      .|...||.
Worm    67 YNKLHKQFGETFGIYFGTQLNINITNEEDIKEVF----IKNFSNFSDRTPPPIIEDNKLKESLLQ 127

  Fly   119 ST-GSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVI 182
            :| .|.|...|..|.|.|....::..||.::.....|::.||:.|..|..:|..::...||||||
Worm   128 NTYESGWKHTRSAIAPIFSTGKMKAMHETIHSKVDLFLEILKEKASSGQKWDIYDDFQGLTLDVI 192

  Fly   183 CDTAMGVSINAMENRSS-SVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDF 246
            ...|..:..|...:|:. ..|.|.|.|| .|.:| .|......:||      ||.||..|.|..|
Worm   193 GKCAFAIDSNCQRDRNDVFYVNARKFIT-NIDIR-HSKIISTSFLF------PELSKLWKVLYRF 249

  Fly   247 TNEIIAKRIEVRKSGLEVGIKADEFSRKK-------MAFLDTLLSSKVD-GRPLTSQELYEEVST 303
            |:  :||.......||     ||.:.|::       :..|..||:.:.| .:|:|.||:.|....
Worm   250 TD--LAKAEIPLVEGL-----ADVYERRRGGEGSDSVDLLKLLLNREDDKSKPMTKQEVIENCFA 307

  Fly   304 FMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEA 368
            |:..|::||::.:.:..||||::|:.|:||:.|..:.....||    |:..|..||:||...||.
Worm   308 FLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEEIMEAKENGGL----TYDSIHNMKYLDYVYKET 368

  Fly   369 QRLYPSV-PFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFD--REKPG 430
            .|.||.| .|..|...||..|.|...|||..:......:..|...:..|.:|.||||:  .||..
Worm   369 LRCYPPVIHFSNRRCLKDITIRGQFYPKGAIVVCLPHTVHRNPENWDSPEEFHPERFENWEEKSS 433

  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467
            ..:::||..|||.|:|.:||.:|.||.::|::..||:
Worm   434 SLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFEL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	139/457 (30%)
cyp-25A3	NP_001040850.1	p450	37..496	CDD:278495	139/457 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810