DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	131/491 - (26%)
Similarity:	245/491 - (49%)	Gaps:	28/491 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLN-KFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHE 65
            |.:.|..    |||:..:.|...||..:|. |..||...|::|.||.:... .:|||.|..:..:
  Fly     4 WTLWCGL----LFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRR-EDILNAFGCFLDK 63

  Fly    66 YGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGSKWHKHRKM 130
            :|...|. |:|....::|::|:.::.|.:|...::|..:|.......|:||.:....:|..|||:
  Fly    64 HGPTIFS-WLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHRKL 127

  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSINAME 195
            :.|||...:|..|..:.|..:...:|||:.:.|.|. .|........||.:...|.||..:...|
  Fly   128 LNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGE-KDLIPLLQSFTLGIATQTTMGSDVKDEE 191

  Fly   196 N-RSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRK 259
            : ||:|::..::.|..|:....||||..:::....|.:...|.:....::.|..:||.:::...:
  Fly   192 SFRSNSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAKTEIRQFIRKIIERKLAEDE 256

  Fly   260 SGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLS 324
            .|....|::::    |..||: |::..:.....|.:.:.:|.:..:|...:||.:.|.:.:.||:
  Fly   257 MGALPSIQSND----KNLFLN-LVTDLMRRGVFTLKNVEDESNIIVFGAFETTANAVYYTLMLLA 316

  Fly   325 RHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVI- 388
            ..|:.||:.|.|...:...:| ..|.::.:...|.:|||.:.|:.|:.|.||.:.|.|.:|..:
  Fly   317 MFPEYQERAFEEIKTIFPNTG-DFDVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLS 380

  Fly   389 DGDIVPKGTTLNLGLLMLGYNDRVF-KDPHKFQPERF---DREKPGPFEYVPFSAGPRNCIGQKF 449
            :|.:||||..:.:.:..:..:.::: .|...|.|:.|   :.:...|:.|:||:.|.|||||.::
  Fly   381 NGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRY 445

  Fly   450 ALLEIKTVVSKIIRN--------FEVLPALDELVSK 477
            ||:..|..::|::||        ||.|..::::..|
  Fly   446 ALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMK 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	119/448 (27%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	117/440 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860