DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp313a5

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_650168.1	Gene:	Cyp313a5 / 41486	FlyBaseID:	FBgn0038005	Length:	487	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	130/488 - (26%)
Similarity:	218/488 - (44%)	Gaps:	60/488 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IVLCAFLALPLFLVTYFELGLLRRKR---MLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWH 64
            :.|..|.|..:.|..||   |..|:|   |:.|..||...|.:|.|.:......:|..|.. .:.
  Fly     2 LTLQIFEAFAIILCVYF---LWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKIRLRTI-LFK 62

  Fly    65 EYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYD-LTHPWLGLGLLTSTGSKWHKHR 128
            .||| ....|||....::...||.:|.|.:|....::|.|.| .....|||||||...:.|::.|
  Fly    63 IYGK-TVLTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAISSCLGLGLLTLKNNHWNERR 126

  Fly   129 KMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSINA 193
            |::.|:|..|.:..|..|:|..:...:..|.:..|||:| :...|.:..:..:.....||..:..
  Fly   127 KLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDGGDI-NLLPELNKWSFKIAAQITMGDEVRN 190

  Fly   194 MEN-RSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEV 257
            ..| ::.::::::|.:...|.:....||.|||||                         .|....
  Fly   191 QANYQNGNLLESYKALNNLIPIGVVMPWLRNKYL-------------------------GKLFSY 230

  Fly   258 RKSGLEVGIKADEFSR----KKM---------AFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGH 309
            .|..||...:::.|.:    ||:         |.:|.:|:....|. |:..::..|.|..:|...
  Fly   231 EKRRLEAATQSNAFIKDIIDKKLSSTDNSSEPALIDRILNLVRIGE-LSYDDVMGEFSNIIFAAS 294

  Fly   310 DTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPS 374
            ||.:..|...:.|::..|..|:.:|.|..:|. .||...:|:..::..:..||..:.|..||.|:
  Fly   295 DTLSITVNNVLILMAMFPKYQDNVFEELAEVF-PSGGEFEASHADLEKLVKLDRVLHETMRLIPA 358

  Fly   375 VPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFK------DPHKFQPERFDREKPGPF 432
            ||.:.|.|.....: :|..:|:|.||.:.:.....|..::.      :|..|.||. .|.:| |:
  Fly   359 VPLLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPEN-KRARP-PY 421

  Fly   433 EYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNF 465
            .|:|||.|.:.|:|.|.:|:..|..::||:||:
  Fly   422 SYLPFSKGKKTCLGWKLSLISAKLALAKILRNY 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	119/454 (26%)
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	119/454 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860