Protein Alignment Cyp4e1 and cyp46a1.4

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_956773.1
• Gene: cyp46a1.4 / 393451
• ZFINID: ZDB-GENE-040426-1224
• Length: 444
• Species: Danio rerio
• Alignment Length: 484
• Identity: 129/484 - (26%)
• Similarity: 226/484 - (46%)
• Gaps: 71/484 - (14%)

  Fly    59 FFGWWHEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYD-----LTHPWLGLGLLT 118
            |..|..:|| ..:|....:|..|:|..|:..:.||.|........||.     ....:||.||:|
Zfish    12 FLQWAEKYG-PVYRINSLHYIAIVVHCPEATKTILMSPKYTKDPFVYRRLFNLFGKRFLGYGLIT 75

  Fly   119 STGSK-WHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVI 182
            :.... |::.|:::.|||..:.|:......:|.|.:.:|:|:::|:........:..:.:|||||
Zfish    76 AVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVI 140

  Fly   183 CDTAMGVSINAMENRSSSVVQAFKDIT--YTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQD 245
            |..|.||.:|.:..:.|....|.:...  .|:.:|  .|:.|   ||      |:..|.:|.::|
Zfish   141 CKVAFGVDLNFLTQKDSPFQNAVELCLNGMTVDLR--DPFFR---LF------PKNWKLIKQIRD 194

  Fly   246 FTNEIIAKR----IEVRKSGLEVG--IKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVS-- 302
             ..|::.|.    |:.||:.::.|  :..|        .|..:|.|..:.....:.:|.:.:.
Zfish   195 -AAELLRKTGEKWIQNRKTAVKNGEDVPKD--------ILTQILKSAEEENVNNTDDLEQMLDNF 250

  Fly   303 -TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIK 366
             ||...|.:||.:.:.||:..|.|:|:..::...|..:|:|..   |:.:.:::....:|...:|
Zfish   251 VTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTK---REISNEDLGKFTYLSQVLK 312

  Fly   367 EAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGP 431
            |..||||:.|...|:..:|.:|||..:|.|.::.....:....::.||||.||.|||||...|.|
Zfish   313 ETLRLYPTAPGTNRWLHEDMIIDGIKIPGGCSVMFSSYVSQRLEKFFKDPLKFDPERFDVNAPKP 377

  Fly   432 FE-YVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSR 495
            :. |.||:.|||.|:||.|:.:|.|.|::|:::.||                  ..|.|.:
Zfish   378 YYCYFPFALGPRTCLGQVFSQMEAKVVLAKLLQRFE------------------FSLVPGQ---- 420

  Fly   496 DAHNHKYDPILSASMTLKSENGLHLRMKQ 524
                 .:|  :..:.||:.::|:...:||
Zfish   421 -----SFD--IKDTGTLRPKSGVICNIKQ 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	123/469 (26%)
cyp46a1.4	NP_956773.1	CYP46A1-like	9..438	CDD:410706	127/478 (27%)