Protein Alignment Cyp4e1 and cyp46a1.2

DIOPT Version :9

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_009292815.1
• Gene: cyp46a1.2 / 393433
• ZFINID: ZDB-GENE-040426-1184
• Length: 501
• Species: Danio rerio
• Alignment Length: 545
• Identity: 141/545 - (25%)
• Similarity: 254/545 - (46%)
• Gaps: 86/545 - (15%)

  Fly     4 VLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLP----LVGNA----HQMGNTPTEILNRFF 60
            |..||||..|:      :..|.:|  .:...||   |    |:|::    ..|.:..:.|.:.|.
Zfish    17 VFTAFLAYCLY------IHHLHQK--YDHIPGP---PRDNFLLGHSPSLTKAMYSDDSLIHDLFL 70

  Fly    61 GWWHEYGKDNFRYWIGYYSNIMVTNPKYMEFILSS----QTLISKSDVYDL-THPWLGLGLLTST 120
            .|..:|| ..:|....:|..|:|..|:..:.||.|    :...|.|.:::| ...:||.||:|:.
Zfish    71 QWAEKYG-PVYRINTLHYIAILVHCPEATKTILMSPKYAKDPFSYSRLFNLFGKRFLGNGLVTAV 134

  Fly   121 GSK-WHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICD 184
            ... |::.|:::.|||..:.|:......:|.|.:.:|:|:::|:........:..:.:||||||.
Zfish   135 DHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVICK 199

  Fly   185 TAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNE 249
            .|.||.:|.:..:.|....|.:.....:.:.|..|      ||...|      |..|.:|...:.
Zfish   200 VAFGVDLNFLTQKDSPFQNAIELCLNGMALDARDP------LFRIFP------KNWKLIQQIRDA 252

  Fly   250 IIAKR------IEVRKSGLEVG--IKADEFSR-KKMAFLDTLLSSKVDGRPLTSQELYEEVSTFM 305
            .:..|      |:.||:.::.|  :..|..:: .|:|..:.:.||:      ..:::.:...||.
Zfish   253 AVLLRKTGEKWIQNRKTAVKNGEDVPKDILTQILKIAEEENVNSSE------DLEQMMDNFVTFF 311

  Fly   306 FEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQR 370
            ..|.:||.:.:.||:..|.|:|:..::...|..:|:|..   |:.:.:::..:.:|...:||..|
Zfish   312 IAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTK---REISNEDLGKLTYLSQVLKETLR 373

  Fly   371 LYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGPFE-Y 434
            |||:.|...|:..:|.:|:|..:|.|.::.....:....::.||||.||.|||||...|.|:. |
Zfish   374 LYPTAPGTNRWLHEDMIINGIKIPGGCSVMFSSFVSQRLEKFFKDPLKFDPERFDENAPKPYYCY 438

  Fly   435 VPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHN 499
            .||:.|||.|:||.|:.:|.|.|::|:::.||                  ..|.|.:
Zfish   439 YPFALGPRTCLGQVFSQMEAKVVLAKLLQRFE------------------FSLVPGQ-------- 477

  Fly   500 HKYDPILSASMTLKSENGLHLRMKQ 524
             .:|  :..:.||:.::|:...:||
Zfish   478 -SFD--IKDTGTLRPKSGVICNIKQ 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	125/458 (27%)
cyp46a1.2	XP_009292815.1	p450	39..495	CDD:278495	131/509 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810