DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	195/515 - (37%)
Similarity:	293/515 - (56%)	Gaps:	36/515 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIVLCAFLALPLFLVTYFELGLLRRKRML----NKFQGPSMLPLVGNAHQMGNTPTEILNRFFG 61
            ||:.|   :...|.|:..::.| .:|:|:|    :...||..:|::|...|..:...|   ...|
  Fly     1 MWLTL---ITGALILLLTWDFG-RKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAE---NIIG 58

  Fly    62 W----WHEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGS 122
            |    :.:||| .||:||...|.|...:.:|.|.||||.||:.|..:|:...|:|..|||.|||.
  Fly    59 WVGEKFDKYGK-TFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVSTGR 122

  Fly   123 KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAM 187
            |||..||:.|.||||.:|:.:.|:|:.:|:..:|.|:|||||....|..:......||||.:.||
  Fly   123 KWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAM 187

  Fly   188 GVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPE--YPEYSKTLKTLQDFTNEI 250
            ||.:||..:.....::|.|.:.|....|.|...:|..:||..|..  :.:....::.:.|||:::
  Fly   188 GVQVNAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKV 252

  Fly   251 IAKRIE-VRKS-------GLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFE 307
            |::|.| ||::       .|.:| .|:..|:.:||.||.||.|.::.:||:..::.|||.|||||
  Fly   253 ISERRETVRRAKADGTYRPLSLG-DAEIGSKSQMALLDILLQSSINNQPLSDADIREEVDTFMFE 316

  Fly   308 GHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLY 372
            |.|||:|||..|:|.::|||:.|:::|.|...|:|... ....|..::..:|:||..|||..|||
  Fly   317 GDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDA-SAPVTQAQLQDLKYLDCVIKETMRLY 380

  Fly   373 PSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERF--DREK-PGPFEY 434
            |.||.|||..:|:..|....:|..|::.|.|.....:...|.||..|:||||  |:|: ...|.|
  Fly   381 PPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQEQGHNTFAY 445

  Fly   435 VPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYI-----STTLGLQP 489
            |||||||:||||||||:||:|.::||::|.:|:||..:||.....:|     ...:||:|
  Fly   446 VPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNFILRSASGINVGLRP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	178/451 (39%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	182/464 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449041
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900