DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp6a23

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	121/527 - (22%)
Similarity:	230/527 - (43%)	Gaps:	103/527 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QMGNTPTEILNRFFGWWHEYGKDN-----FR-YWIGYYSNIMVTNPKYMEF----ILSSQTLISK 101
            |....|.::.:..:|...::.|..     || |:..|..::......|..|    :::...|:.:
  Fly    27 QRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFAGFYFFFTRSAVITDLELVKR 91

  Fly   102 SDVYDLTH-------------PWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTK 153
            ..:.|..|             | |...|.:..|.||...|..:||.|....:::...::    .|
  Fly    92 VLIKDFNHFENRGIFYNEIDDP-LSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPII----VK 151

  Fly   154 FIDQLKKVADG------GNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTI 212
            ..::::|:...      |.:.:..:.....|.|||.:.|.|::.|:::|.::..|        ||
  Fly   152 VGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFV--------TI 208

  Fly   213 KMRAFSPWKRNKYLFHFAPEYPEYSKTLK------TLQDFTNEIIAKRIEVRKSGLEVGIKADEF 271
            ..||....:....|......:|:.|:.|:      .::||...|:...|:.|       ::.:|
  Fly   209 GKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNVQDVEDFYTSIVRNTIDYR-------LRTNE- 265

  Fly   272 SRKKMAFLDTLL--------SSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPD 328
              |:..|:|:|:        .:..||  |:..|:..:...|...|.:|:::.:|||:|.|:...|
  Fly   266 --KRHDFMDSLIEMYEKEQAGNTEDG--LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQD 326

  Fly   329 EQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGD-- 391
            .|::|..|..:|:  |....:.|::.|..||:|:..:.|..|.||.:..:.|.|:.|:..:..
  Fly   327 IQDQLRAEINNVL--SKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKY 389

  Fly   392 IVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDRE----KPGPFEYVPFSAGPRNCIGQKFALL 452
            .:.||||:.:..|.:.|:..::.:|.||:||||..|    :|. ..::||..|||||||.:|.|:
  Fly   390 FIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPS-CTWLPFGEGPRNCIGLRFGLM 453

  Fly   453 EIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENG 517
            :....::.:||.::              .|.:...|...|            .:..|:.|.:|||
  Fly   454 QACVGLAYLIRGYK--------------FSVSTETQIPMK------------FVVKSILLSAENG 492

  Fly   518 LHLRMKQ 524
            :||::::
  Fly   493 IHLKVEK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	111/470 (24%)
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	117/512 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820