DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	123/574 - (21%)
Similarity:	228/574 - (39%)	Gaps:	135/574 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIVLCAFLALPLFL---VTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGW 62
            :|::|...:.|..:|   ..||      |.|.:......|..|: ||..|:     ..|...||
  Fly     4 IWLLLLTIVTLNFWLRHKYDYF------RSRGIPHLPPSSWSPM-GNLGQL-----LFLRISFG- 55

  Fly    63 WHEYGKDNFRYW-----------IGYY----SNIMVTNPKYMEFIL--SSQTLISKSDVYDLTHP 110
                  |.||..           :|::    ..:||.:|:.:..:|  :....:::.:..|...|
  Fly    56 ------DLFRQLYADPRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNRFESADAGDP 114

  Fly   111 WLGLGLLTSTGSK---WHKHRKMITPAF------------HFNILQDFHEVMNENSTKFIDQLKK 160
               :|.||...:|   |.:.|:.::..|            ..::..|..:.:|.   |..|:|::
  Fly   115 ---MGALTLPLAKYHHWKESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNR---KLGDRLER 173

  Fly   161 VADGGNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKY 225
            |...|.:      ....|.||..:....:::..:....|.::...|::..|      :|.|...:
  Fly   174 VLPLGRM------CQLYTTDVTGNLFYSLNVGGLRRGRSELITKTKELFNT------NPRKVLDF 226

  Fly   226 L-FHFAPEYPEYSKTLKTLQDFT---NEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK 286
            : ..|.|::....|.....:|:.   ..::....|..|..|...::..:.||.         |:.
  Fly   227 MSVFFLPKWTGVLKPKVFTEDYARYMRHLVDDHHEPTKGDLINQLQHFQLSRS---------SNH 282

  Fly   287 VDGRP--LTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRD 349
            ....|  :.||     ....:..|.:|:::.:||.:|.|::.||.||:|.:|..:...::.   .
  Fly   283 YSQHPDFVASQ-----AGIILLAGFETSSALMGFTLYELAKAPDIQERLRSELREAFISTA---T 339

  Fly   350 ATFQEISTMKHLDLFIKEAQRLYPSVPFIGR---------FTEKDYVIDGDIVPKGTTLNLGLLM 405
            .::..:.|:.:|.:...||.||||:..|:.|         |:.:.:|  ..|||.|....:.:|.
  Fly   340 LSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTSSASEGFSLQPHV--DFIVPPGMPAYISILG 402

  Fly   406 LGYNDRVFKDPHKFQPERFDREKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467
            |..::|.:.:|..|.||||..|:.   .|..|:||.|||..|||.:..:|::|..:..|::.:.|
  Fly   403 LHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWV 467

  Fly   468 LPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLR 521
                                   |...|.....:::|   .|..|:|||.::||
  Fly   468 -----------------------ETCERTVSEIRFNP---KSFMLESENEIYLR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	105/484 (22%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	109/527 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010