DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp9b1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	124/515 - (24%)
Similarity:	218/515 - (42%)	Gaps:	98/515 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AFLALPLFLVTYFELGLLRRK---RMLNKFQGPSM-----LPLVGN----AHQMGNTPTEILNRF 59
            :|:.:.|.|.|   :|||..|   .....|:|.::     .|.:||    |.|..:...:| :.|
  Fly     2 SFVEICLVLAT---IGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQI-SEF 62

  Fly    60 FGWWHEYGKDNFRYWIGYYS----NIMVTNPKYMEFILSSQTLISKSDVYDL----THPWLGLG- 115
                  |.:......:|.::    .|.:.:|:          ||.|..|.|.    .|..|.:.
  Fly    63 ------YNRTRHHKLVGLFNLRTPMIQINDPQ----------LIKKICVKDFDHFPNHQTLNIPN 111

  Fly   116 -------LLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKK---VADGGNIF-- 168
                   |.......|...|.::||.|....:::...:|||:..:.::.||.   :|.|.|.|
  Fly   112 ERLVNDMLNVMRDQHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFEL 176

  Fly   169 DFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTI-KMRAFSPWKRNKYLFHF--- 229
            |.:...:.|:.|||..||.|:.:|:.::..:..        :|| |..|||   |......|
  Fly   177 DMKVLCNKLSNDVIATTAFGLKVNSFDDPENEF--------HTIGKTLAFS---RGLPFLKFMMC 230

  Fly   230 --APEYPEYSKTLKTLQDFTN-----EIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKV 287
              ||:...:.|.  |:.|.||     .::...::.|:.        ...:|..|  :..|:.:|.
  Fly   231 LLAPKVFNFFKL--TIFDSTNVEYFVRLVVDAMQYREK--------HNITRPDM--IQLLMEAKK 283

  Fly   288 DGRP-LTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDAT 351
            :.:. .|..|:..:...|.|...:..::.:....|.|.|:.|.||:|:.|..:...|. .|...|
  Fly   284 ESKDNWTDDEIVAQCFIFFFAAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEAL-KGAPLT 347

  Fly   352 FQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPK------GTTLNLGLLMLGYND 410
            :.....|.::|:.|.|:.|.:.......|...|||.:..|...|      |..:|:.:..|.:::
  Fly   348 YDAAQEMTYMDMVISESLRKWTLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDE 412

  Fly   411 RVFKDPHKFQPERF-DREKPG--PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEV 467
            |.|..|.:|.|||| :|.|..  |:.|:||..|||:|||.::|:::.|.::..::.|:::
  Fly   413 RFFPQPQRFDPERFSERRKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKI 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	115/485 (24%)
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	114/477 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900