DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4e3

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	357/528 - (67%)
Similarity:	431/528 - (81%)	Gaps:	7/528 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHE 65
            ||:.:.|.|.|||..:.|||....:|:::|.:|.||:.:|::|||:::|..|.|||:.||.||::
  Fly     1 MWLAVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYD 65

  Fly    66 YGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGSKWHKHRKM 130
            ||||||.:||||.|:|::||||.:|:||:||.||.||.:|||.|||||.|||||.||||||||||
  Fly    66 YGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHKHRKM 130

  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSINAME 195
            |||:|||||||||||||||||.||:.||||.:.|..|.||||.|:||||||||||||||.|||||
  Fly   131 ITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPINAME 195

  Fly   196 NRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKS 260
            .|.||:||||:|:.|.|.||||.|:||:..:|...||:..|.||||||||||.:||.||:...::
  Fly   196 QRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQN 260

  Fly   261 GLEVGIKAD---EFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYL 322
            |   |.|.|   ...|||||||||||||.:||||||.||:|||||||||||||||||||.|:|||
  Fly   261 G---GSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYL 322

  Fly   323 LSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYV 387
            ||||||.|.||:.|||:||| ..:.|..:||||:.||:||||||||||:|||||||||:.:|||.
  Fly   323 LSRHPDVQRKLYREQCEVMG-HDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYD 386

  Fly   388 IDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGPFEYVPFSAGPRNCIGQKFALL 452
            |:|.||||||||||.|::||||||:|||||.|:||||:.|||.||||:|||||||||||||||||
  Fly   387 INGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPAPFEYLPFSAGPRNCIGQKFALL 451

  Fly   453 EIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENG 517
            |:|||:||::|:||||||:|||||.||.::|.|||.|.||..|:|..|||||||||.:||||:||
  Fly   452 ELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNG 516

  Fly   518 LHLRMKQR 525
            ||||:::|
  Fly   517 LHLRLRER 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	305/437 (70%)
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	305/436 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449014
Domainoid	1	1.000	160	1.000	Domainoid score	I1269
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	1	1.000	-	-		H111093
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	12	11.800