Protein Alignment Cyp4e1 and CYP26C1

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_899230.2
• Gene: CYP26C1 / 340665
• HGNCID: 20577
• Length: 522
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 119/534 - (22%)
• Similarity: 195/534 - (36%)
• Gaps: 148/534 - (27%)

  Fly     4 VLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFG----W-- 62
            :|||.|.|.|....:....:|.|.|       .|.|||...:  || .|      |||    |
Human    19 LLCAGLLLSLAQHLWTLRWMLSRDR-------ASTLPLPKGS--MG-WP------FFGETLHWLV 67

  Fly    63 ----WHEYGKDNFRYWIGYYSNIM------VTNPKYMEFILSSQTLISKSDVYDLTHPWLGL-GL 116
                :|...::  ||...:.::::      |:..:.:..||..:..:.:|......|..||. .|
Human    68 QGSRFHSSRRE--RYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTL 130

  Fly   117 LTSTGSKWHKHRKMITPAFHFNILQDF---------HEVMNENSTKFIDQLKKVADGGNIFDFQE 172
            |.:.|....:.||::...|....|:.:         |||.:           ..|.||.:
Human   131 LGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRS-----------WCAAGGPV----- 179

  Fly   173 EAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYS 237
                                       ||..|.|.:|:.:..|         .|.....:..:.:
Human   180 ---------------------------SVYDASKALTFRMAAR---------ILLGLRLDEAQCA 208

  Fly   238 KTLKTLQDFTNEIIAKRIEVRKSGLEVGIKA-DEFSR------------KKMA----FLDTLL-S 284
            ...:|.:.....:.:..::|..|||..||:| |:..|            .|.|    .||.:: |
Human   209 TLARTFEQLVENLFSLPLDVPFSGLRKGIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHS 273

  Fly   285 SKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGR- 348
            ::..|...:.|||.|.....:|....||.|.....|.||.:||....|:..|    :.|.||||
Human   274 ARELGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREE----LVAQGLGRA 334

  Fly   349 ----------------------DATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGD 391
                                  |.:...:..::::|..:||..||.|.|....|...:.:.:||.
Human   335 CGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGY 399

  Fly   392 IVPKGTTLNLGLLMLGYNDRVFKDPHK-FQPERF------DREKPGPFEYVPFSAGPRNCIGQKF 449
            .:|||.::...:........|::.|.: |.||||      .|.....|.|:||..|.|:|:||:.
Human   400 QIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQEL 464

  Fly   450 ALLEIKTVVSKIIR 463
            |...::.:..:::|
Human   465 AQAVLQLLAVELVR 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	98/460 (21%)
CYP26C1	NP_899230.2	CYP26C1	59..508	CDD:410729	102/478 (21%)