Protein Alignment Cyp4e1 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 531
• Identity: 136/531 - (25%)
• Similarity: 252/531 - (47%)
• Gaps: 79/531 - (14%)

  Fly     3 IVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW---- 63
            :||.|.:.:.|:.......||.:::.:    .||..||.:|.          :||.:.|.|
Mouse    12 LVLLAIILVLLYRYGTRTHGLFKKQGI----PGPKPLPFLGT----------VLNYYTGIWKFDM 62

  Fly    64 ---HEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLT-----ST 120
               .:||| .:..:.|....:::|:|:.::.:|....|    .|:.....:..:|:::     |.
Mouse    63 ECYEKYGK-TWGLFDGQTPLLVITDPETIKNVLVKDCL----SVFTNRREFGPVGIMSKAISISK 122

  Fly   121 GSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDT 185
            ..:|.::|.:::|.|....|::...|:.:.....:..|::.|:.|.....::.....::|||..|
Mouse   123 DEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVITST 187

  Fly   186 AMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFH-FAPEYPEYSKTLKTLQDFTN- 248
            :.||:::::.|.....|:..|..   :::..|.|...:..||. ..|.|     .:..:..|.|
Mouse   188 SFGVNVDSLNNPEDPFVEEAKKF---LRVDFFDPLLFSVVLFPLLTPVY-----EMLNICMFPND 244

  Fly   249 --EIIAKRIE-VRKSGLEVGIKADEFSRKKMAFLDTLLSS------KVDGRPLTSQELYEEVSTF 304
              |...|.:: :::|.|      |...:.::.||..:::|      |...:..::.|:..:...|
Mouse   245 SIEFFKKFVDRMQESRL------DSNQKHRVDFLQLMMNSHNNSKDKDSHKAFSNMEITVQSIIF 303

  Fly   305 MFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQ 369
            :..|::||:|.:.|.:|.|:.|||.|:||   |.::..|.......|...:..|::||:.:.|..
Mouse   304 ISAGYETTSSTLSFTLYCLATHPDIQKKL---QAEIDKALPNKATPTCDTVMEMEYLDMVLNETL 365

  Fly   370 RLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG---P 431
            ||||.|..:.|..:||..::|..:|||:.:.:....|.::.:.:.||.:||||||.:|..|   |
Mouse   366 RLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDP 430

  Fly   432 FEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV----SKDGYISTTLGLQPAEK 492
            :.|:||..|||||||.:|||:.:|..|:|:::||...|..:..:    |:.|.      ||| ||
Mouse   431 YVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGI------LQP-EK 488

  Fly   493 K------SRDA 497
            .      .|||
Mouse   489 PIVLKVVPRDA 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	119/459 (26%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	118/454 (26%)