DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	469	Identity:	119/469 - (25%)
Similarity:	212/469 - (45%)	Gaps:	73/469 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GPSMLPLVGNA--HQMGNTPTEILNRFFGWWHEYGKDNFRYWIGYYSN----IMVTNPKYMEFIL 93
            ||..||.||.|  :..|     |.|.......:|||    .| |.|..    ::||:   :|.|
Zfish    39 GPRPLPFVGTALSYSKG-----ICNFDIECSKKYGK----VW-GIYDGRLPLLLVTD---LEMI- 89

  Fly    94 SSQTLISKSDVY-----------DLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVM 147
              :|::.| |.|           ||..|:.. |:......:|.:.|..::|.|....|::...:.
Zfish    90 --KTILVK-DCYSTFTNRRNMNPDLVGPFAD-GITLVKDERWRRIRSSLSPYFTSGRLKEIFPIA 150

  Fly   148 NENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKD----- 207
            ..::.:||..::| .|.......::.....:|||:..::..|..:::.|.....|.:.|.
Zfish   151 MTHADRFIKNMEK-KDPNLPLKIKDVVAPYSLDVVASSSFSVDFDSINNPDDPFVTSIKSFFNIN 214

  Fly   208 -ITYTIKMRAFSPWKRNKY----LFHFAPEYPE-YSKTLKTLQDFTNEIIAKRIEVRKSGLEVGI 266
             ::....:.||.|...|..    :..|:....: |.|.|:.::|..||... |::..|..::..|
Zfish   215 PLSPLFLLLAFCPSAANLLAKMGISVFSRSTTDFYYKALRKIKDEHNESNG-RVDFLKLMIQNQI 278

  Fly   267 KADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQE 331
            ..|:..       ||.....|.|  ||..|:..:...|:..|::||::.:.:.:|.|:.:||..|
Zfish   279 PDDQVK-------DTASEQPVKG--LTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLE 334

  Fly   332 KLFNE-----QCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGD 391
            ||..|     ..|:        ..|:..:..|.:|::.|.|:.|::|:.|.:.|..:|...|:|.
Zfish   335 KLVEEIDKNFPLDI--------PITYDALMRMDYLEMAIHESMRVFPAGPRLERVCKKTVEINGI 391

  Fly   392 IVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGPFE---YVPFSAGPRNCIGQKFALLE 453
            .:||.|.:.:.|.:|..:..:::.|::|:||||..|......   ::||..|||||||.:|||:.
Zfish   392 TIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKTEINQCAFMPFGLGPRNCIGMRFALMM 456

  Fly   454 IKTVVSKIIRNFEV 467
            :|.:|.|:::.:.|
Zfish   457 MKLLVVKLLQKYTV 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	119/469 (25%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	119/469 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810