DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	148/538 - (27%)
Similarity:	252/538 - (46%)	Gaps:	84/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PLFLVTYFELGLLRRK----RMLNKFQGPSMLPLVGNAHQMGNTP--------TEILNRFFGWWH 64
            ||.|:| ..:.:|.||    |:.:...||...||:|||..:|...        ||:.:||..
  Fly     5 PLLLIT-LTIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGA--- 65

  Fly    65 EYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQ--------TLISKSDVYDLTHPWLGLGLLTSTG 121
                 .:|..:|         |:...|:.|::        ..:.|:|.:....|.:|.|||.|.|
  Fly    66 -----TYRLRLG---------PQLWVFLHSAEETRQALHDPTLRKADTFMQLEPLIGNGLLISHG 116

  Fly   122 SKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTA 186
            :.|.:.|:::||||...:|:.|...:..:..:.:.:|.  |..|...:..|......||.|.||:
  Fly   117 AHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLG--ATRGAFLEVTEPLFACLLDAIVDTS 179

  Fly   187 MGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEII 251
            ||..::......|.::|||...:..:..|..:|...:.::|.....:.:..:.|:.:......:|
  Fly   180 MGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVI 244

  Fly   252 AKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGV 316
            .||   .|..|::|    |.:.:....|||||.:|.:|:.|:.:|:.:|::||:|.|.||||:.:
  Fly   245 EKR---AKELLDMG----EPAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFVFAGVDTTTAAM 302

  Fly   317 GFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRF 381
            .|.:|.|::.|:.|.:|..|..||    .|........::.:.:|:..|||..|||..||..||.
  Fly   303 SFVLYALAKFPETQTRLRKELQDV----ALDETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQ 363

  Fly   382 TEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDRE----KPGPFEYVPFSAGPR 442
            |.:...|.|.....|.||.:.:..|.::...:.||:.|:|||:..|    .|..|.|:|||.||.
  Fly   364 TTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPH 428

  Fly   443 NCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILS 507
            .|||::::||.:|.:.::::|.|:                  :.|.|.:...|          |.
  Fly   429 VCIGRRYSLLLMKLLTARLVREFQ------------------MELSPEQAPLR----------LE 465

  Fly   508 ASMTLKSENGLHLR-MKQ 524
            |.|.||::.|:::. :||
  Fly   466 AQMVLKAQQGINVSFLKQ 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	129/454 (28%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	138/507 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	1	0.950	-	0	Normalized mean entropy	S4824
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	8.910