DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	193/539 - (35%)
Similarity:	299/539 - (55%)	Gaps:	57/539 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQG--PSM--LPLVGNAHQMGN-TPTEILNRFF 60
            |.:||...|.:...:.:.|.|.|   |.:.:..||  ||:  :||:|.|.||.: .|..:.::|.
  Fly     1 MLVVLLVALLVTRLVASLFRLAL---KELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFA 62

  Fly    61 GWWHEYGKDNFRYWIGYYSNIMVT-NPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGSKW 124
            .:...:|:......:|:.  :||| .|::::.:|..|..:.|..:|.....|||.|||.|.|.:|
  Fly    63 EYVKRFGRSFMGTVLGHV--VMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEW 125

  Fly   125 HKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGV 189
            |..||:|||.|||:||:.|.||.:..|:..:::|:.::.|..:.:.........||:|.:|||||
  Fly   126 HTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGV 190

  Fly   190 SINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFA-PE-YPEYSKTLKTLQDFTNEII- 251
            :::| :...|.||.|.||:|..:..|...|.....:||... |. :.:....:..|.:|||.||
  Fly   191 NVDA-QGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIE 254

  Fly   252 -AKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSG 315
             .:|:..|::.       .:...|..|.|||||.:.|||:|||.:::.:||:||:|||||||||.
  Fly   255 QRRRLLAREAN-------QDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSA 312

  Fly   316 VGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGR 380
            |.|.:||||||...|:||| |:..:.....|.|.....:.:|:.:|...:||:.||||.:|.:.|
  Fly   313 VSFCLYLLSRHEAVQQKLF-EELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVAR 376

  Fly   381 FTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPER-FDREKP--GPFEYVPFSAGPR 442
            ..|||.|||...:|.||.:.:.|..|..::.:|.||..||||| ...|.|  .|:.|:|||||||
  Fly   377 CLEKDLVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPR 441

  Fly   443 NCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILS 507
            |||||||||||:||:|:|:||::::||     :..|        ::|                 |
  Fly   442 NCIGQKFALLEMKTMVTKVIRHYQLLP-----MGAD--------VEP-----------------S 476

  Fly   508 ASMTLKSENGLHLRMKQRL 526
            ..:.|:|::|:::.::.||
  Fly   477 IKIVLRSKSGVNVGLRPRL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	175/447 (39%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	180/491 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449037
Domainoid	1	1.000	160	1.000	Domainoid score	I1269
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	1	0.950	-	0	Normalized mean entropy	S4824
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.850