DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and cyp19a1a

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_571229.3	Gene:	cyp19a1a / 30390	ZFINID:	ZDB-GENE-990415-43	Length:	517	Species:	Danio rerio

Alignment Length:	543	Identity:	128/543 - (23%)
Similarity:	213/543 - (39%)	Gaps:	101/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDN 70
            |...|..|.|:....|.:...:...:...|||..        .|..|.....||.  |...|..:
Zfish    40 CGATATILLLLLCLLLAIRHHRPHKSHIPGPSFF--------FGLGPVVSYCRFI--WSGIGTAS 94

  Fly    71 FRYWIGYYSNIMVTNPKYME----FILSSQTLI--SKSDVYDLTHPWLGLGLLTST-GSK----- 123
                 .||      |.||.:    :|...:|||  ..|.||.:    |...|.||. |||
Zfish    95 -----NYY------NSKYGDIVRVWINGEETLILSRSSAVYHV----LRKSLYTSRFGSKLGLQC 144

  Fly   124 ----------------WHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQE 172
                            |.|.|.....|.....||...|:...::...:|.|.::.|.....|...
Zfish   145 IGMHEQGIIFNSNVALWKKVRAFYAKALTGPGLQRTMEICTTSTNSHLDDLSQLTDAQGQLDILN 209

  Fly   173 EAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYS 237
            ....:.:||.....:||.:|  |:.....:..:.|...|:.:      |.:.| |.....:.::.
Zfish   210 LLRCIVVDVSNRLFLGVPLN--EHDLLQKIHKYFDTWQTVLI------KPDVY-FRLDWLHKKHK 265

  Fly   238 KTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVS 302
            :..:.|||    .|...||.:|..|....|.|.     :.|...|:.::..|. |:::.:.:.|.
Zfish   266 RDAQELQD----AITALIEQKKVQLAHAEKLDH-----LDFTAELIFAQSHGE-LSAENVRQCVL 320

  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367
            ..:....||.:..:.|.:.||.::||.:.|:..|...|:.    |:......:|.::.|:.||.|
Zfish   321 EMVIAAPDTLSISLFFMLLLLKQNPDVELKILQEMDSVLA----GQSLQHSHLSKLQILESFINE 381

  Fly   368 AQRLYPSVPFIGRFTEKDYVIDGDIVPKGTT--LNLGLLMLGYNDRVFKDPHKFQPERFDREKPG 430
            :.|.:|.|.|..|....|.||:|..|.|||.  ||:|.:   :....|..|::|..:.|.:..|.
Zfish   382 SLRFHPVVDFTMRRALDDDVIEGYNVKKGTNIILNVGRM---HRSEFFSKPNQFSLDNFHKNVPS 443

  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLP----ALDELVSKDGYISTTLGLQPAE 491
            .| :.||.:|||:|:|:..|::.:|:::..::..|.|.|    .::.:..     :..|..||.|
Zfish   444 RF-FQPFGSGPRSCVGKHIAMVMMKSILVALLSRFSVCPMKACTVENIPQ-----TNNLSQQPVE 502

  Fly   492 KKSRDAHNHKYDPILSASMTLKS 514
            :.|.          ||..:.|::
Zfish   503 EPSS----------LSVQLILRN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	114/464 (25%)
cyp19a1a	NP_571229.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589900
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950