DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	157/551 - (28%)
Similarity:	265/551 - (48%)	Gaps:	78/551 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLCAFLALPLFLVTYFELGLLRRK---------RMLNKFQGPSMLPLVGNAHQMGNTPTEILNRF 59
            ||.|.|...|||:  |.|.|...|         |.|:.|..|.     |....:|:....:.|
  Rat    23 VLSALLLFLLFLL--FRLLLQAFKLFSDFRITCRRLSCFPEPP-----GRHWLLGHMSMYLPN-- 78

  Fly    60 FGWWHEYGKDNFR-----------YWIGYYSNIMV-TNPKYMEFILSSQTLISKSD--VYDLTHP 110
                 |.|..|.:           .|:|.:..::| .:|.|::.:|.:...|:..|  .|....|
  Rat    79 -----EKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKP 138

  Fly   111 WLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNI--FDFQEE 173
            |||.|||.|.|:||.:||:::||||||:||:.:.::.|::......:.::....|::  ||..|.
  Rat   139 WLGDGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQSVNIMHAKWRRHLAEGSVTSFDMFEH 203

  Fly   174 AHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSK 238
            ...:|||.:.......|.:..| :.|..:.:..:::..:..|.:.......::::...:...:.:
  Rat   204 VSLMTLDSLQKCVFSYSSDCQE-KLSDYISSIIELSALVVRRQYRLHHYLDFIYYLTADGRRFRQ 267

  Fly   239 TLKTLQDFTNEII-AKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-VDGRPLTSQELYEEV 301
            ...|:.:||.|:| .:|..:|:.|.|..:||.:  .|.:.|:|.||.:| .:|:.|:.:::..|.
  Rat   268 ACDTVHNFTTEVIQQRRRALRELGAEAWLKAKQ--GKTLDFIDVLLLAKDEEGKELSDEDIRAEA 330

  Fly   302 STFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIK 366
            .||||||||||:||:.:|::.|:::|:.|:|...|..:||....| .:..:.:::.:....:.||
  Rat   331 DTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGREL-EELDWDDLTQLPFTTMCIK 394

  Fly   367 EAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP- 429
            |:.|.:|.|..|.|...:|..: ||.|:|||....:.:....||..|:.|...:.|.|||.:.|
  Rat   395 ESLRQFPPVTLISRRCTEDIKLPDGRIIPKGIICLVSIYGTHYNPLVWPDSKVYNPYRFDPDIPQ 459

  Fly   430 --GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEK 492
              .|..:|||||||||||||.||:.|::.||:..:..|.                  |.:....|
  Rat   460 QRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFR------------------LSVDRTRK 506

  Fly   493 KSRDAHNHKYDPILSASMTLKSENGLHLRMK 523
            ..|           ...:.|::||||.|.::
  Rat   507 VRR-----------KPELILRTENGLWLNVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	134/456 (29%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	136/473 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650