DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	138/466 - (29%)
Similarity:	239/466 - (51%)	Gaps:	53/466 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 WIGYYSNIM-VTNPKYMEFILSSQTLISKSDVYDL--THPWLGLGLLTSTGSKWHKHRKMITPAF 135
            |:|....:: :.:|.::..:|.:..|::..|...|  ..||||.||..|:|.||.:||:::||||
  Rat    91 WLGPVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRFLKPWLGDGLFLSSGDKWSRHRRLLTPAF 155

  Fly   136 HFNILQDFHEVMNENSTKFIDQLKKVA-DGGNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSS 199
            ||:||:.:.::.|::......:.|.:. :|....:..|....:|||.:.....|...|..|: .|
  Rat   156 HFDILKPYVKIFNQSVNIMHAKWKHLCLEGSARLEMFENISLMTLDSLQKCLFGFDSNCQES-PS 219

  Fly   200 SVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKS-GLE 263
            ..:.|..:::..|..|:...:....:|::...:...:.|....:.:||:.:|.:|..:..| |.:
  Rat   220 EYISAILELSSLIIKRSQQLFLYLDFLYYRTADGRRFRKACDLVHNFTDAVIRERRRLLSSQGTD 284

  Fly   264 VGIKADEFSRKK-MAFLDTLLSSKVD-GRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRH 326
            ..:::...|:.| :.|:|.||.:|.: |:.|:.:::..|..||||.|||||.|.:.:.:|.|:||
  Rat   285 EFLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARH 349

  Fly   327 PDEQEKLFNEQCDVMGASGLGRDATFQEI-----STMKHLDLFIKEAQRLY-PSVPFIGRFTEKD 385
            |:.||:...|..:::      ||...:||     :.:..|.:.|||:.||: |::..:.|.|:..
  Rat   350 PEYQERCRQEVWELL------RDREPEEIEWDDLAQLPFLTMCIKESLRLHPPAIDLLRRCTQDI 408

  Fly   386 YVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFD---REKPGPFEYVPFSAGPRNCIGQ 447
            .:.||.::|||....:.:..:.:|..|:.||..|.|.|||   |:|..|..::||||||||||||
  Rat   409 VLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVFDPFRFDSENRQKRSPLSFIPFSAGPRNCIGQ 473

  Fly   448 KFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTL 512
            .||:.|:|.||:..:..|.|||  |:                            .:|.....:.|
  Rat   474 TFAMNEMKVVVALTLLRFRVLP--DD----------------------------KEPRRKPEIIL 508

  Fly   513 KSENGLHLRMK 523
            ::|.||.|||:
  Rat   509 RAEGGLWLRME 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	127/410 (31%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	135/461 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640