Protein Alignment Cyp4e1 and CYP4V2

DIOPT Version :9

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 184/502 - (36%)
• Similarity: 267/502 - (53%)
• Gaps: 55/502 - (10%)

  Fly    40 PLVGNAHQMGNTPTEILNRFFGWWHEY-GKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSD 103
            ||||:|..|.....|...:...:..|| .....:.|:|....:.:.|.:.:|.||:|...|.||.
Human    58 PLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSS 122

  Fly   104 VYDLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIF 168
            :|....||||||||||||:||...|||:||.|||.||:||.::|||.:...:.:|:|
Human   123 MYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK-------- 179

  Fly   169 DFQEEA----HYLT---LDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYL 226
            ...:||    .|:|   ||:||:||||.:|.|..|..|..|:|...::..|..|...||......
Human   180 HINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLW 244

  Fly   227 FHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEV---GIKADEFSRKKMAFLDTLLSSKVD 288
            :....|..|:.|:|:.|..|||.:||:|.....:..:.   |..:.....|:.||||.|||...|
Human   245 YLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDD 309

  Fly   289 -GRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATF 352
             |..|:.:::.|||.||||||||||.:.:.:::|||..:|:.|:|:.:|..||.|.|  .|.||.
Human   310 EGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS--DRPATV 372

  Fly   353 QEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPH 417
            :::..:::|:..|||..||:||||...|...:|..:.|..|.|||...:....|..:.|.|.:|.
Human   373 EDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPE 437

  Fly   418 KFQPERFDREKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDG 479
            :||||||..|..   .|:.|||||||||||||||||::|.||::|.|:|:|.:
Human   438 EFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWI------------ 490

  Fly   480 YISTTLGLQPAEKKSRDAHNHKYDPI-LSASMTLKSENGLHLRMKQR 525
                             ..|.|.:.: |...:.|:..||:.:::|:|
Human   491 -----------------ESNQKREELGLEGQLILRPSNGIWIKLKRR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	176/443 (40%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	182/497 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.750