Protein Alignment Cyp4e1 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 156/547 - (28%)
• Similarity: 253/547 - (46%)
• Gaps: 90/547 - (16%)

  Fly     7 AFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDN- 70
            :.|.|.|.|:...:| .|.|:.:|...|            |....|:..|   ||...|:..|.
Human    23 SLLILLLLLIKAAQL-YLHRQWLLKALQ------------QFPCPPSHWL---FGHIQEFQHDQE 71

  Fly    71 --------------FRYWI-GYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTHPWLGLG 115
                          ..||| |....:.:.:|.||:.||      .:||     .|....|.:|.|
Human    72 LQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVIL------GRSDPKSHGSYKFLAPRIGYG 130

  Fly   116 LLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLD 180
            ||...|..|.:||:|:|||||.:||:.:..:|.::....:|:.:::....:..:..:....:|||
Human   131 LLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLD 195

  Fly   181 VICDTAMGVSINAMENRSS-SVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQ 244
            .|..:|.....:...:|:| |.:||..|:...:.....:.:..|..::..........:..:...
Human   196 TIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAH 260

  Fly   245 DFTNEIIAKRIEVRKSGLEVGIKADEFSRKK-MAFLDTLLSSKVD-GRPLTSQELYEEVSTFMFE 307
            ..|:::    |::||:.|:...:.::..||: :.|||.||.:|:: |..|:.::|..||.|||||
Human   261 QHTDQV----IQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFE 321

  Fly   308 GHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLY 372
            |||||.||:.:.:|.|:.||..||:...|   :.|..|.|...|:..:..|.:..:.||||.|||
Human   322 GHDTTASGISWILYALATHPKHQERCREE---IHGLLGDGASITWNHLDQMPYTTMCIKEALRLY 383

  Fly   373 PSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGPFE--- 433
            |.||.|||........ ||..:|||..:.|.:..|.:|.:|:.:...|.|.||   .||..:
Human   384 PPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRF---APGSAQHSH 445

  Fly   434 -YVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDA 497
             ::|||.|.|||||::||:.::|...:..:..||:||....:
Human   446 AFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRI----------------------- 487

  Fly   498 HNHKYDPILSASMTLKSENGLHLRMKQ 524
                  ||..|.:.|||:||:|||:::
Human   488 ------PIPMARLVLKSKNGIHLRLRR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	135/463 (29%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	144/500 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650