DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp4a12a

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_803125.2	Gene:	Cyp4a12a / 277753	MGIID:	88612	Length:	508	Species:	Mus musculus

Alignment Length:	553	Identity:	156/553 - (28%)
Similarity:	263/553 - (47%)	Gaps:	94/553 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEY 66
            ::.:.:.|:|.|.|....:|.|.|:.             |:.:..|..:.|:..|   ||  |:.
Mouse    18 YLQVASVLSLLLLLFKTAQLYLHRQW-------------LLSSTQQFPSPPSHWL---FG--HKI 64

  Fly    67 GKD-----------NF----RYWI-GYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTHP 110
            .||           ||    ..|: |....|.|.:|.||:.||      .:||     .|....|
Mouse    65 LKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLIL------GRSDPKANGSYRFLAP 123

  Fly   111 WLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAH 175
            |:|.|||...|..|.:||:|:|||||::||:.:.|:|.::....:|:.:::....:..:......
Mouse   124 WIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIFRHIT 188

  Fly   176 YLTLDVI--CDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSK 238
            .:|||.|  |..:...|:. ::.:..|.:||.:|:...:..|..:.:.:|..::..:....:.:.
Mouse   189 LMTLDTIMKCAFSHEGSVQ-LDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANS 252

  Fly   239 TLKTLQDFTNEII-AKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVD-GRPLTSQELYEEV 301
            ..|...|.|:::| ::||:::.......:|    .::::.|||.||.:::: |:.|:.::|..||
Mouse   253 ACKLAHDHTDQVIKSRRIQLQDEEELEKLK----KKRRLDFLDILLFARMENGKSLSDKDLRAEV 313

  Fly   302 STFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIK 366
            .||||||||||.||:.:..|.|:.:|:.|::...|   :....|.|...|:.::..|.:..:.||
Mouse   314 DTFMFEGHDTTASGISWIFYALATNPEHQQRCRKE---IQSLLGDGTSITWNDLDKMPYTTMCIK 375

  Fly   367 EAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG 430
            ||.|:||.||.:.|........ ||..:|||..:.|....|.:|..|:.:|..|.|.||   .||
Mouse   376 EALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRF---APG 437

  Fly   431 ----PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAE 491
                ...::|||.|.|||||::||:.|:|..|:..:..||:||                  .|..
Mouse   438 SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP------------------DPTR 484

  Fly   492 KKSRDAHNHKYDPILSASMTLKSENGLHLRMKQ 524
            .           ||....:.|||:||:||.:|:
Mouse   485 V-----------PIPIPRIVLKSKNGIHLHLKK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	136/464 (29%)
Cyp4a12a	NP_803125.2	p450	52..502	CDD:278495	144/500 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650