DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	143/473 - (30%)
Similarity:	236/473 - (49%)	Gaps:	57/473 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 NFR----YWIG-YYSNIMVTNPKYMEFILSSQTLISKSD--VYDLTHPWLGLGLLTSTGSKWHKH 127
            |||    .|:| .|..:.:.:|..:..:|.:...::..:  :|....||||.|||.|.|.||:.|
  Rat    84 NFRDIHLSWVGPVYPILRLVHPNVIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGEKWNHH 148

  Fly   128 RKMITPAFHFNILQDFHEVMNEN-STKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSI 191
            |:::||||||:||:.:.::.|:: :|......:..|.|....|..|....:|||.:.........
  Rat   149 RRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSARLDMFEHISLMTLDSLQKCIFSFDS 213

  Fly   192 NAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEII-AKRI 255
            |..|: :|..:.|..:::..|..|...|:....:|::...:...:.|....:.:||:.:| .:|.
  Rat   214 NCQES-NSEYIAAILELSSLIVKRQRQPFLYLDFLYYLTADGRRFRKACDVVHNFTDAVIRERRS 277

  Fly   256 EVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVD-GRPLTSQELYEEVSTFMFEGHDTTTSGVGFA 319
            .:...|::..:|| ....|.:.|:|.||.:|.: |:.|:..::..|..||||.|||||.|.:.:.
  Rat   278 TLNTQGVDEFLKA-RAKTKTLDFIDVLLLAKDEHGKGLSDVDIRAEADTFMFGGHDTTASALSWI 341

  Fly   320 VYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEI-----STMKHLDLFIKEAQRLYPSVPFIG 379
            :|.|:|||:.||:...|..:::      ||...:||     :.:..|.:.|||:.||:|.|..|.
  Rat   342 LYNLARHPEYQERCRQEVRELL------RDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVLLIS 400

  Fly   380 RFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP---GPFEYVPFSAG 440
            |...:|.|: ||.::|||....:.:..:.:|..|:.||..:.|.|||.|.|   .|..::|||||
  Rat   401 RCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAG 465

  Fly   441 PRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPI 505
            |||||||.||:.|||..::..:..|.|||  |:                            .:|.
  Rat   466 PRNCIGQTFAMSEIKVALALTLLRFCVLP--DD----------------------------KEPR 500

  Fly   506 LSASMTLKSENGLHLRMK 523
            ....:.|::|.||.||::
  Rat   501 RKPELILRAEGGLWLRVE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	133/417 (32%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	141/468 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348601
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650