Protein Alignment Cyp4e1 and Cyp4a8

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_113793.2
• Gene: Cyp4a8 / 266674
• RGDID: 628846
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 541
• Identity: 150/541 - (27%)
• Similarity: 251/541 - (46%)
• Gaps: 90/541 - (16%)

  Fly    11 LPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKD------ 69
            |.||....|   .|.|:.:|...|            |..:.|:   :.|||  |:..||
  Rat    29 LLLFKTAQF---YLHRRWLLRATQ------------QFPSPPS---HWFFG--HKIPKDQEFQDI 73

  Fly    70 -----NF----RYWI-GYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTHPWLGLGLLTS 119
                 ||    ..|: |....|.|.:|.||:.||      .:||     .|....||:|.|||..
  Rat    74 LTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLIL------GRSDPKSHHSYRFLAPWIGYGLLLL 132

  Fly   120 TGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVI-- 182
            .|..|.:||:|:|||||::.|:.:..:|.::....:|:.:::....:..:..:....:|||.|
  Rat   133 NGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMK 197

  Fly   183 CDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFT 247
            |..:...|:. ::.:..|.::|.:|:......|..:.:.:|..::..:....:.....:...:.|
  Rat   198 CAFSQEGSVQ-LDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHT 261

  Fly   248 NEIIAKRIEVRKSGLEVGIKADEFSRK-KMAFLDTLLSSKVD-GRPLTSQELYEEVSTFMFEGHD 310
            :::    |:.||:.|:...:..:..:| ::.|||.||.:::: |..|:.::|..||.||||||||
  Rat   262 DQV----IKSRKAQLQDEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHD 322

  Fly   311 TTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSV 375
            ||.||:.:..|.|:.:|:.|:....|   :....|.|...|:.::..|.:..:.||||.|:||.|
  Rat   323 TTASGISWIFYALATNPEHQQGCRKE---IQSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPV 384

  Fly   376 PFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP-GPFEYVPFS 438
            ..:.|........ ||..:|||.|:.|....|.:|..|:.:|..|.|.||..|.. ....::|||
  Rat   385 TAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPESSRHSHSFLPFS 449

  Fly   439 AGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYD 503
            .|.|||||::||:.|:|..|:..:..||:||....:
  Rat   450 GGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRI----------------------------- 485

  Fly   504 PILSASMTLKSENGLHLRMKQ 524
            ||....:.|||:||::||:|:
  Rat   486 PIPIPRLVLKSKNGIYLRLKK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	133/478 (28%)
Cyp4a8	NP_113793.2	CYP4B-like	70..503	CDD:410771	131/475 (28%)