Protein Alignment Cyp4e1 and CYP4Z1

DIOPT Version :9

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 162/560 - (28%)
• Similarity: 268/560 - (47%)
• Gaps: 106/560 - (18%)

  Fly     3 IVLCAFLALPLFLVTYFELGLLRRK----RMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW 63
            |:||  ::|.||.|    :.|.:|:    |.|:.|..|.       ||               |:
Human    18 ILLC--MSLLLFQV----IRLYQRRRWMIRALHLFPAPP-------AH---------------WF 54

  Fly    64 HEYGKDNF--------------RY------WIGYYSNIM-VTNPKYMEFILSSQTLISKSDV-YD 106
              ||...|              :|      |:|.::... |.:|.|.:.:|..|.  .||.| :.
Human    55 --YGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD--PKSAVSHK 115

  Fly   107 LTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKK-VADGGNIFDF 170
            :...|:|.||:|..||||.|||:::.|.|:.:||:.|..:|:|:....:::.:: :|....:..|
Human   116 ILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELF 180

  Fly   171 QEEAHYLTLDVI--CDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEY 233
            | ....:|||.|  |..:...||. :::...|.::|..:::.....|..:....|..:|.|:.:.
Human   181 Q-HVSLMTLDSIMKCAFSHQGSIQ-LDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQG 243

  Fly   234 PEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDG-RPLTSQEL 297
            ..:||..:.|..||.::    |:.||..|:..:|.|...:::..|||.|||:|.:. :..:..:|
Human   244 QIFSKFNQELHQFTEKV----IQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADL 304

  Fly   298 YEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLD 362
            ..||.||||.|||||:|.:.:.:|.|:::|:.|::..:|..:::|.   |...|::.:|.|.:..
Human   305 QAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD---GSSITWEHLSQMPYTT 366

  Fly   363 LFIKEAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDR 426
            :.|||..|||..|..|.|..:|.... ||..:|.|.|:.:.:..|.:|...::||..|.|.||.|
Human   367 MCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSR 431

  Fly   427 ---EKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQ 488
               ||..|:.::|||||.||||||.||::|.|..|:..:..|::.|
Human   432 ENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAP------------------- 477

  Fly   489 PAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMKQRLVC 528
                      :|...|.....:.|||:||:|:..|:  ||
Human   478 ----------DHSRPPQPVRQVVLKSKNGIHVFAKK--VC 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	138/464 (30%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	147/516 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750