DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	465	Identity:	137/465 - (29%)
Similarity:	235/465 - (50%)	Gaps:	54/465 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 WIG-YYSNIMVTNPKYMEFILSSQTLISKSD--VYDLTHPWLGLGLLTSTGSKWHKHRKMITPAF 135
            |:| .|..:.:.:|.::..:|.:...::..:  :|....||||.|||.|.|.||..||:::||||
Mouse    91 WVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGDKWSHHRRLLTPAF 155

  Fly   136 HFNILQDFHEVMNENSTKFIDQLKKVAD-GGNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSS 199
            ||:||:.:.::.|::......:.:.:|. |.:..|..|....:|||.:......|..|..|: .|
Mouse   156 HFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLDMFEHISLMTLDSLQKCIFSVDSNCQES-DS 219

  Fly   200 SVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEII-AKRIEVRKSGLE 263
            ..:.|..:::..:..|...|:.....|::...:...:.|....:.:||:.:| .:|..:...|:|
Mouse   220 KYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKACDLVHNFTDAVIKERRSTLNTQGVE 284

  Fly   264 VGIKADEFSRKKMAFLDTLLSSKVD-GRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHP 327
            . :|| :...|.:.|:|.||.::.: |:.|:::::..|..||||.|||||||.:.:.:|.|:|||
Mouse   285 F-LKA-KAKTKTLDFIDVLLMAEDEHGKGLSNEDIRAEADTFMFGGHDTTTSALSWILYNLARHP 347

  Fly   328 DEQEKLFNEQCDVMGASGLGRDATFQEI-----STMKHLDLFIKEAQRLYPSVPFIGRFTEKDYV 387
            :.||:...|..:::      ||...:||     :.:..|.:.|||:.||:|.|..|.|...:|.:
Mouse   348 EYQERCRQEVQELL------RDRDSEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVL 406

  Fly   388 I-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP---GPFEYVPFSAGPRNCIGQK 448
            : ||..:|||....:.:..:.:|..|:.||..:.|.|||.|.|   .|..::|||||.||||||.
Mouse   407 LPDGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGTRNCIGQT 471

  Fly   449 FALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSASMTLK 513
            ||:.|||..::..:..|.:||  |:                            .:|.....:.|:
Mouse   472 FAMSEIKVALALTLLRFRILP--DD----------------------------KEPRRKPELILR 506

  Fly   514 SENGLHLRMK 523
            :|.||.||::
Mouse   507 AEGGLWLRVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	127/409 (31%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	135/460 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845193
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650