Protein Alignment Cyp4e1 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 127/516 - (24%)
• Similarity: 209/516 - (40%)
• Gaps: 96/516 - (18%)

  Fly     1 MWIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGP----SMLPLVGNAHQMGNTPTEILNRFFG 61
            |.::.|||   .|.||....|......::....:.|    |.:|.:|:|...|.:|.|.|...:
Human    35 MLLIACAF---TLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAY- 95

  Fly    62 WWHEYGK--------DNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYD-LTHPWLGLGLL 117
              .:||.        ..|.|.:|..:..::.|.|..:        ::..|||. ||.|..|.|:.
Human    96 --EKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED--------LNAEDVYSRLTTPVFGKGVA 150

  Fly   118 TSTGSK-WHKHRKMITPAF-------HFNILQ----DFHEVMNENSTKFIDQLKKVADGGNIFDF 170
            ....:. :.:.:||:....       |.:|::    ::.|...|:..|            |:|:.
Human   151 YDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEK------------NVFEA 203

  Fly   171 QEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPE 235
            ..|...||..   ....|..|.:..|  ..|.|.:.|:.......|   |....:|  ..|.:..
Human   204 LSELIILTAS---HCLHGKEIRSQLN--EKVAQLYADLDGGFSHAA---WLLPGWL--PLPSFRR 258

  Fly   236 YSKTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKV-DGRPLTSQELYE 299
            ..:..:.::|    |..|.|:.|:...|   |.|:       .|.|||.:.. ||||||..|:..
Human   259 RDRAHREIKD----IFYKAIQKRRQSQE---KIDD-------ILQTLLDATYKDGRPLTDDEVAG 309

  Fly   300 EVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLF 364
            .:...:..|..|:::...:..:.|:|....|:|.:.||..|.|.:  ....|:.::..:..||..
Human   310 MLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGEN--LPPLTYDQLKDLNLLDRC 372

  Fly   365 IKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPH----KFQPERFD 425
            |||..||.|.:..:.|.......:.|..:|.|..:.:...:   |.|: ||..    .|.|:|:.
Human   373 IKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTV---NQRL-KDSWVERLDFNPDRYL 433

  Fly   426 REKPG---PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYIST 483
            ::.|.   .|.||||.||...|||:.||.::|||:.|.::|.:|.     :|:  |||..|
Human   434 QDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF-----DLI--DGYFPT 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	108/445 (24%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	110/454 (24%)