DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and CYP26A1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_000774.2	Gene:	CYP26A1 / 1592	HGNCID:	2603	Length:	497	Species:	Homo sapiens

Alignment Length:	529	Identity:	115/529 - (21%)
Similarity:	206/529 - (38%)	Gaps:	90/529 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIVLCA-----FLALPL--------FLVTYFELGLLRRK--RMLNKFQGPSMLPLVGNAHQMGN 50
            :|.:.|.     ..||||        |.....::.|.|||  :|..:..|     .:...|..|.
Human    27 LWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYG-----FIYKTHLFGR 86

  Fly    51 TPTEILNRFFGWWHEYGKDNF-RYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGL 114
            ....::          |.||. |..:|.:..:.|..|..:..||.|..|   |:::|.:|
Human    87 PTVRVM----------GADNVRRILLGEHRLVSVHWPASVRTILGSGCL---SNLHDSSH----- 133

  Fly   115 GLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTL 179
                      .:.:|:|..||....|:.:..|:.|.....::|.....:.|.:  ...|...|..
Human   134 ----------KQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLL--VYPEVKRLMF 186

  Fly   180 DVICDTAMGVSINAMENRSS--SVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKT 242
            .:.....:|.......:..|  .:|:||:::|            ||  ||....:.| :|...:.
Human   187 RIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT------------RN--LFSLPIDVP-FSGLYRG 236

  Fly   243 LQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVD-GRPLTSQELYEEVSTFMF 306
            ::  ...:|..|||........|::|.|..:.....|..|:....: |..|..|.|.:..:..:|
Human   237 MK--ARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLF 299

  Fly   307 EGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGL------GRDATFQEISTMKHLDLFI 365
            .||:||.|.....:..|..:|...:|:..|    :.:.||      ......:.:..:|::...|
Human   300 GGHETTASAATSLITYLGLYPHVLQKVREE----LKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 360

  Fly   366 KEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERF---DRE 427
            ||..||.|.||...|...|.:.::|..:|||..:...:........:|.:..:|.|:||   ..|
Human   361 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPE 425

  Fly   428 KPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEK 492
            ....|.::||..|.|:|:|::||.:.:|....::.|:.:.     :|::....:.|:..:.|.:.
Human   426 DASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDW-----QLLNGPPTMKTSPTVYPVDN 485

  Fly   493 -KSRDAHNH 500
             .:|..|.|
Human   486 LPARFTHFH 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	97/447 (22%)
CYP26A1	NP_000774.2	p450	14..492	CDD:299894	113/525 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910