DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and CYP4A11

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens

Alignment Length:	535	Identity:	157/535 - (29%)
Similarity:	261/535 - (48%)	Gaps:	66/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AFLALPLFLVTYFELGLLRR--KRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKD 69
            :.|.|.|.|:...:|.|.|:  .:.|.:|..|....|.|:..::  ...:.|.|...|...: ..
Human    23 SLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQEL--QQDQELQRIQKWVETF-PS 84

  Fly    70 NFRYWI-GYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTHPWLGLGLLTSTGSKWHKHR 128
            ...:|: |....:.:.:|.||:.||      .:||     .|....||:|.|||...|..|.:||
Human    85 ACPHWLWGGKVRVQLYDPDYMKVIL------GRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHR 143

  Fly   129 KMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVI--CDTAMGVSI 191
            :|:|||||::||:.:..:|.::....:|:.:::....:..:..:....:|||.|  |..:...||
Human   144 RMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSI 208

  Fly   192 NAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIE 256
            . ::..|.|.:||..|:...:..|..:.:.:|..::..........:..:.....|:::    |:
Human   209 Q-VDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQV----IQ 268

  Fly   257 VRKSGLEVGIKADEFSRKK-MAFLDTLLSSKVD-GRPLTSQELYEEVSTFMFEGHDTTTSGVGFA 319
            :||:.|:...:.::..||: :.|||.||.:|:: |..|:.::|..||.||||||||||.||:.:.
Human   269 LRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWI 333

  Fly   320 VYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEK 384
            :|.|:.||..||:...|...::|.   |...|:..:..|.:..:.||||.||||.||.|||....
Human   334 LYALATHPKHQERCREEIHSLLGD---GASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELST 395

  Fly   385 DYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGPFE----YVPFSAGPRNC 444
            .... ||..:|||..:.|.:..|.:|.:|:.:|..|.|.||   .||..:    ::|||.|.|||
Human   396 PVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRF---APGSAQHSHAFLPFSGGSRNC 457

  Fly   445 IGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDPILSAS 509
            ||::||:.|:|...:..:..||:||....:                             ||..|.
Human   458 IGKQFAMNELKVATALTLLRFELLPDPTRI-----------------------------PIPIAR 493

  Fly   510 MTLKSENGLHLRMKQ 524
            :.|||:||:|||:::
Human   494 LVLKSKNGIHLRLRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	135/449 (30%)
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	146/501 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650