Protein Alignment Cyp4e1 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 137/530 - (25%)
• Similarity: 246/530 - (46%)
• Gaps: 80/530 - (15%)

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW--- 63
            |::|...|.| |:|......||.:|..:    .||:.|||:||          :|:...|.|
Human    12 WLLLAVSLVL-LYLYGTRTHGLFKRLGI----PGPTPLPLLGN----------VLSYRQGLWKFD 61

  Fly    64 ----HEYGKDNFRYWIGYYSN----IMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTST 120
                .:|||    .| |.|..    :.:|:|..:..:|..:..    .|:........:|.:.|.
Human    62 TECYKKYGK----MW-GTYEGQLPVLAITDPDVIRTVLVKECY----SVFTNRRSLGPVGFMKSA 117

  Fly   121 GS-----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLD 180
            .|     :|.:.|.:::|.|....|::...::.:.....:..|::.|:.|.....::.....::|
Human   118 ISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMD 182

  Fly   181 VICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTL--KT 242
            ||..|:.||:|:::.|.....|::.|..   :|.....|...:..||.| .|.:...:.:|  |.
Human   183 VITGTSFGVNIDSLNNPQDPFVESTKKF---LKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKD 244

  Fly   243 LQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-----VDGRPLTSQELYEEVS 302
            ..:|.::.:.:   ::||.|      ::..:.::.||..::.|:     ...:.|:..||..:..
Human   245 TINFLSKSVNR---MKKSRL------NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300

  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367
            .|:|.|::||:|.:.|.:|.|:.|||.|:||..|...|:....   ..|:..:..|::||:.:.|
Human   301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA---PPTYDAVVQMEYLDMVVNE 362

  Fly   368 AQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG-- 430
            ..||:|....:.|..:||..|:|..:|||:.:.:....|.::.:.:.:|.:|:||||.::|..
Human   363 TLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 427

  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYIS---TTLGLQPAEK 492
            |:.|.||..|||||||.:|||:.:|..:.::::||...|.      |:..|.   .|.||...||
Human   428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC------KETQIPLKLDTQGLLQPEK 486

  Fly   493 ------KSRD 496
                  .|||
Human   487 PIVLKVDSRD 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	116/457 (25%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	115/453 (25%)