Protein Alignment Cyp4e1 and CYP3A4

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 135/529 - (25%)
• Similarity: 249/529 - (47%)
• Gaps: 77/529 - (14%)

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGW---- 62
            |::|...|.| |:|......||.::..:    .||:.||.:||          ||:...|:
Human    12 WLLLAVSLVL-LYLYGTHSHGLFKKLGI----PGPTPLPFLGN----------ILSYHKGFCMFD 61

  Fly    63 ---WHEYGKDNFRYWIGYYSN----IMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTST 120
               ..:|||    .| |:|..    :.:|:|..::.:|..:..    .|:....|:..:|.:.|.
Human    62 MECHKKYGK----VW-GFYDGQQPVLAITDPDMIKTVLVKECY----SVFTNRRPFGPVGFMKSA 117

  Fly   121 GS-----KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLD 180
            .|     :|.:.|.:::|.|....|::...::.:.....:..|::.|:.|.....::.....::|
Human   118 ISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMD 182

  Fly   181 VICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQD 245
            ||..|:.||:|:::.|.....|:..|.:   ::.....|:..:..:|.|.....|........::
Human   183 VITSTSFGVNIDSLNNPQDPFVENTKKL---LRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244

  Fly   246 FTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-----VDGRPLTSQELYEEVSTFM 305
            .||.:......:::|.||      :..:.::.||..::.|:     ...:.|:..||..:...|:
Human   245 VTNFLRKSVKRMKESRLE------DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFI 303

  Fly   306 FEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDA--TFQEISTMKHLDLFIKEA 368
            |.|::||:|.:.|.:|.|:.|||.|:|| .|:.|.:    |...|  |:..:..|::||:.:.|.
Human   304 FAGYETTSSVLSFIMYELATHPDVQQKL-QEEIDAV----LPNKAPPTYDTVLQMEYLDMVVNET 363

  Fly   369 QRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERF---DREKPG 430
            .||:|....:.|..:||..|:|..:|||..:.:....|..:.:.:.:|.||.||||   :::...
Human   364 LRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428

  Fly   431 PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLG--LQPAEK- 492
            |:.|.||.:|||||||.:|||:.:|..:.::::||...|..:..:.    :..:||  ||| ||
Human   429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP----LKLSLGGLLQP-EKP 488

  Fly   493 -----KSRD 496
                 :|||
Human   489 VVLKVESRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	116/456 (25%)
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	115/452 (25%)