DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and CYP3A7

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens

Alignment Length:	528	Identity:	133/528 - (25%)
Similarity:	246/528 - (46%)	Gaps:	75/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW--- 63
            |::|...|.| |:|......||.::..:    .||:.||.:|||          |:...|:|
Human    12 WLLLAVSLIL-LYLYGTRTHGLFKKLGI----PGPTPLPFLGNA----------LSFRKGYWTFD 61

  Fly    64 HEYGKDNFRYWIGYYS----NIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGS-- 122
            .|..|...:.| |.|.    .:.:|:|..::.:|..:..    .|:....|:..:|.:.:..|
Human    62 MECYKKYRKVW-GIYDCQQPMLAITDPDMIKTVLVKECY----SVFTNRRPFGPVGFMKNAISIA 121

  Fly   123 ---KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICD 184
               :|.:.|.:::|.|....|::...::.:.....:..|::.|:.|.....:......::|||..
Human   122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITS 186

  Fly   185 TAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTLKTLQDFTN 248
            |:.||||:::.|.....|:..|.:   ::.....|:..:..:|.| .|.....:.|:     |..
Human   187 TSFGVSIDSLNNPQDPFVENTKKL---LRFNPLDPFVLSIKVFPFLTPILEALNITV-----FPR 243

  Fly   249 EIIA---KRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-----VDGRPLTSQELYEEVSTFM 305
            ::|:   |.::..|.|     :..|..:.::.||..::.|:     ...:.|:..||..:...|:
Human   244 KVISFLTKSVKQIKEG-----RLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFI 303

  Fly   306 FEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQR 370
            |.|::||:|.:.|.:|.|:.|||.|:|:..|...|:....   ..|:..:..:::||:.:.|..|
Human   304 FAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA---PPTYDTVLQLEYLDMVVNETLR 365

  Fly   371 LYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERF---DREKPGPF 432
            |:|....:.|..:||..|:|..:|||..:.:...:|.::.:.:.:|.||.||||   :::...|:
Human   366 LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY 430

  Fly   433 EYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTL---GLQPAEK-- 492
            .|.||.:|||||||.:|||:.:|..:.::::||...|.      |:..|...|   ||...||
Human   431 IYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPC------KETQIPLKLRFGGLLLTEKPI 489

  Fly   493 ----KSRD 496
                :|||
Human   490 VLKAESRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	114/458 (25%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	122/489 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810