Protein Alignment Cyp4e1 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 133/528 - (25%)
• Similarity: 246/528 - (46%)
• Gaps: 75/528 - (14%)

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW--- 63
            |::|...|.| |:|......||.::..:    .||:.||.:|||          |:...|:|
Human    12 WLLLAVSLIL-LYLYGTRTHGLFKKLGI----PGPTPLPFLGNA----------LSFRKGYWTFD 61

  Fly    64 HEYGKDNFRYWIGYYS----NIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGS-- 122
            .|..|...:.| |.|.    .:.:|:|..::.:|..:..    .|:....|:..:|.:.:..|
Human    62 MECYKKYRKVW-GIYDCQQPMLAITDPDMIKTVLVKECY----SVFTNRRPFGPVGFMKNAISIA 121

  Fly   123 ---KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICD 184
               :|.:.|.:::|.|....|::...::.:.....:..|::.|:.|.....:......::|||..
Human   122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITS 186

  Fly   185 TAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTLKTLQDFTN 248
            |:.||||:::.|.....|:..|.:   ::.....|:..:..:|.| .|.....:.|:     |..
Human   187 TSFGVSIDSLNNPQDPFVENTKKL---LRFNPLDPFVLSIKVFPFLTPILEALNITV-----FPR 243

  Fly   249 EIIA---KRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-----VDGRPLTSQELYEEVSTFM 305
            ::|:   |.::..|.|     :..|..:.::.||..::.|:     ...:.|:..||..:...|:
Human   244 KVISFLTKSVKQIKEG-----RLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFI 303

  Fly   306 FEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQR 370
            |.|::||:|.:.|.:|.|:.|||.|:|:..|...|:....   ..|:..:..:::||:.:.|..|
Human   304 FAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA---PPTYDTVLQLEYLDMVVNETLR 365

  Fly   371 LYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERF---DREKPGPF 432
            |:|....:.|..:||..|:|..:|||..:.:...:|.::.:.:.:|.||.||||   :::...|:
Human   366 LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY 430

  Fly   433 EYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTL---GLQPAEK-- 492
            .|.||.:|||||||.:|||:.:|..:.::::||...|.      |:..|...|   ||...||
Human   431 IYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPC------KETQIPLKLRFGGLLLTEKPI 489

  Fly   493 ----KSRD 496
                :|||
Human   490 VLKAESRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	114/459 (25%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	110/451 (24%)