DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	539	Identity:	161/539 - (29%)
Similarity:	264/539 - (48%)	Gaps:	84/539 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LFLVTYFE-LGLLRRK----RMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDNFR 72
            :.:||..: |.||.|:    |.|:.|.||....|.|:|.::..|..  |::...|     .:.|.
Mouse    21 ILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGG--LDKVVTW-----TEQFP 78

  Fly    73 Y----WIGYYSNIM-VTNPKYMEFILSSQTLISKSD-----VYDLTHPWLGLGLLTSTGSKWHKH 127
            |    |:|.:...: :..|.|      ::.:.|:.|     |||....|:|.|||...|.||.:|
Mouse    79 YAHPLWLGQFIVFLNIYEPDY------AKAVYSRGDPKAAYVYDFFLQWIGKGLLVLEGPKWFQH 137

  Fly   128 RKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSIN 192
            ||::||.||:::|:.:..:..|::...:|:.:|.|.....||...:..::.||.:.....|...:
Mouse   138 RKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDS 202

  Fly   193 AMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEV 257
            .:.:..:|...|..|:|..::.|..|....|.:::...|....:.:..:...|.|:.:|.:
Mouse   203 GLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHTDHVIRQ---- 263

  Fly   258 RKSGLEVGIKADEFSRKKMA------FLDTLLSSKVD-GRPLTSQELYEEVSTFMFEGHDTTTSG 315
            ||:.|:     ||..:||:.      |||.||.::.: |..|:..:|..||.|||||||||||||
Mouse   264 RKAALQ-----DEKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDTTTSG 323

  Fly   316 VGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQ--EISTMKHLDLFIKEAQRLYPSVPFI 378
            :.:.:|.::.:|..|::...|..:::|    .|| :||  :::.|.:|.:.:||..||||.||.:
Mouse   324 ISWFLYCMALYPMHQQRCREEVREILG----DRD-SFQWDDLAQMTYLTMCMKECFRLYPPVPQV 383

  Fly   379 GRFTEKDYV-IDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREK---PGPFEYVPFSA 439
            .|...|... :||..:|.|:.::|.:..|..|..|:.||..|.|.||..|.   ..||.::||||
Mouse   384 YRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSA 448

  Fly   440 GPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKYDP 504
            ||||||||:||:.|:|.|.:..:..||..|...::                             |
Mouse   449 GPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKI-----------------------------P 484

  Fly   505 ILSASMTLKSENGLHLRMK 523
            |....:.|:|:||:||.:|
Mouse   485 IKVPQLILRSKNGIHLYLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	142/457 (31%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	149/508 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845257
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650