Protein Alignment Cyp4e1 and Cyp4a12b

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_758510.2
• Gene: Cyp4a12b / 13118
• MGIID: 3611747
• Length: 508
• Species: Mus musculus
• Alignment Length: 553
• Identity: 156/553 - (28%)
• Similarity: 263/553 - (47%)
• Gaps: 94/553 - (16%)

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEY 66
            ::.:.:.|:|.|.|....:|.|.|:.             |:.:..|..:.|:..|   ||  |:.
Mouse    18 YLQVASVLSLLLLLFKTAQLYLHRQW-------------LLSSTQQFPSPPSHWL---FG--HKI 64

  Fly    67 GKD-----------NF----RYWI-GYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTHP 110
            .||           ||    ..|: |....|.|.:|.||:.||      .:||     .|....|
Mouse    65 LKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLIL------GRSDPKAHGSYRFLAP 123

  Fly   111 WLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAH 175
            |:|.|||...|..|.:||:|:|||||::||:.:.|:|.::....:|:.:::....:..:..:...
Mouse   124 WIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHIT 188

  Fly   176 YLTLDVI--CDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSK 238
            .:|||.|  |..:...|:. ::.:..|.:||.:|:.....:|..:.:.:|..::..:......:.
Mouse   189 LMTLDTIMKCAFSHEGSVQ-LDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANS 252

  Fly   239 TLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRK-KMAFLDTLLSSKVD-GRPLTSQELYEEV 301
            ..:...|.|:::    |:.|:|.|:...:.::..:| ::.|||.||.:::: |:.|:.::|..||
Mouse   253 ACQLAHDHTDQV----IKSRRSQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEV 313

  Fly   302 STFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIK 366
            .||||||||||.||:.:..|.|:.:|:.|::...|   :....|.|...|:.::..|.:..:.||
Mouse   314 DTFMFEGHDTTASGISWIFYALATNPEHQQRCRKE---IQSLLGDGASITWNDLDKMPYTTMCIK 375

  Fly   367 EAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG 430
            ||.|:||.||.:.|........ ||..:|||..:.|....|.:|..|:.:|..|.|.||   .||
Mouse   376 EALRIYPPVPSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRF---APG 437

  Fly   431 ----PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAE 491
                ...::|||.|.|||||::||:.|:|..|:..:..||:||                  .|..
Mouse   438 SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLP------------------DPTR 484

  Fly   492 KKSRDAHNHKYDPILSASMTLKSENGLHLRMKQ 524
            .           ||....:.|||:||:||.:|:
Mouse   485 V-----------PIPIPRIVLKSKNGIHLHLKK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	139/481 (29%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	138/478 (29%)