DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	551	Identity:	158/551 - (28%)
Similarity:	264/551 - (47%)	Gaps:	89/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEY 66
            ::.:.:.|.|.|.||...:. .|.|:.:|..||               ..|:...:.|||  ||.
Mouse    18 FLQVASVLGLLLLLVKAVQF-YLHRQWLLKAFQ---------------QFPSPPFHWFFG--HEK 64

  Fly    67 GK------------DNF-----RYWIGYYSNIMVTNPKYMEFILSSQTLISKSD-----VYDLTH 109
            .|            :||     |::.|..:.:.|.:|.||:.||      .:||     .|.|..
Mouse    65 FKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVIL------GRSDPKANGAYRLLA 123

  Fly   110 PWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEA 174
            ||:|.|||...|..|.:||:|:|||||::||:.:.:.|.::....:|:.:::||..:..:..:..
Mouse   124 PWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHI 188

  Fly   175 HYLTLDVI--CDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYS 237
            ..:|||.:  |..:...|:. ::....:.:||..|:......|..:.:.:|..::..:.......
Mouse   189 SLMTLDTVMKCAFSHKGSVQ-VDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAK 252

  Fly   238 KTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRK-KMAFLDTLLSSKVD-GRPLTSQELYEE 300
            :..:...|.|:.:    |::||..|:...:.::..:| ::.|||.||.:::: |..::.::|..|
Mouse   253 QACQLAHDHTDGV----IKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAE 313

  Fly   301 VSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFI 365
            |.||||||||||.|||.:..|.|:.|||.|::...|   |....|.|...|:..:..:.:..:.|
Mouse   314 VDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREE---VQSLLGDGSSITWDHLDQIPYTTMCI 375

  Fly   366 KEAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKP 429
            |||.||||.||.|.|........ ||..:|||..:.|.:..|.:|.:|:.:|..|.|.||..:.|
Mouse   376 KEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSP 440

  Fly   430 -GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKK 493
             ....::|||.|.|||||::||:.|:|.:|:..:..||:||                  .|...
Mouse   441 RHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLP------------------DPTRV- 486

  Fly   494 SRDAHNHKYDPILSASMTLKSENGLHLRMKQ 524
                      |:..|.:.|||:||::|.:|:
Mouse   487 ----------PMPLARLVLKSKNGIYLHLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	137/462 (30%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	146/495 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640