DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	515	Identity:	132/515 - (25%)
Similarity:	247/515 - (47%)	Gaps:	64/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW---- 63
            :||.|.:.:.|:.......||.:::.:    .||..||.:|.          :||.:.|.|
Mouse    12 LVLLAIILVLLYRYGTCTHGLFKKQGI----PGPKPLPFLGT----------VLNYYKGLWKFDM 62

  Fly    64 ---HEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGS--- 122
               .:||| .:..:.|.....::|:|:.::.:|..:..    .|:.....:..:|:::.:.|
Mouse    63 ECYEKYGK-TWGLFDGQIPLFVITDPETIKNVLVKECF----SVFTNRQDFFPVGIMSKSISLAK 122

  Fly   123 --KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDT 185
              :|.::|.:::|.|....|::...|:.:.....:..|::.|:.|.....::.....::|||..|
Mouse   123 DEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIIST 187

  Fly   186 AMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTL--KTLQDFT 247
            ..||:|:::.|.....|:..|.:   ::...|.|...:..||.| .|.|...:..:  |...:|.
Mouse   188 TFGVNIDSLNNPEDPFVENAKKV---LRFDYFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEFF 249

  Fly   248 NEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSS------KVDGRPLTSQELYEEVSTFMF 306
            .:.:.:..|.|         .|...:.::.|:..::.:      |...:.|:..|:..:...|:|
Mouse   250 KKFVDRMTENR---------LDSKQKHRVDFIYLMMEAYNKSKDKDSHKALSEIEITAQSIIFIF 305

  Fly   307 EGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDA--TFQEISTMKHLDLFIKEAQ 369
            .|::||:|.:.|.||.|:.|||.|:|| .|:.|    ..|...|  |:..:..|::||:.:.|..
Mouse   306 AGYETTSSILSFTVYSLATHPDIQKKL-QEEID----EALPNKAPPTYDTVMAMEYLDMVLNETL 365

  Fly   370 RLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG---P 431
            ||||....:.|..:||..|:|..:|||:|:.:...:|.::.:.:.:|.:||||||.:|..|   |
Mouse   366 RLYPITNRLQRVCKKDVEINGIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDP 430

  Fly   432 FEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAE 491
            :.|:||..|||||||.:|||:.:|..:.|:::||...|..:..:...  :|..|.|||.:
Mouse   431 YVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQIPLK--LSRELLLQPVK 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	120/460 (26%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	126/484 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810