Protein Alignment Cyp4e1 and Cyp3a11

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_031844.1
• Gene: Cyp3a11 / 13112
• MGIID: 88609
• Length: 504
• Species: Mus musculus
• Alignment Length: 533
• Identity: 138/533 - (25%)
• Similarity: 251/533 - (47%)
• Gaps: 82/533 - (15%)

  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQ---GPSMLPLVGNAHQMGNTPTEILNRFFGWW 63
            |::|.      :.||..:..|  .||..|.|.|   ||..||.:|.          :||.:.|.|
Mouse    12 WVLLA------ISLVLLYRYG--TRKHELFKKQGIPGPKPLPFLGT----------VLNYYKGLW 58

  Fly    64 -------HEYGKDNFRYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLT--- 118
                   .:||| .:..:.|....:.||:|:.::.:|..:..    .|:.....:..:|:::
Mouse    59 KFDMECYKKYGK-TWGLFDGQTPLLAVTDPETIKNVLVKECF----SVFTNRRDFGPVGIMSKAI 118

  Fly   119 --STGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDV 181
              |...:|.::|.:::|.|....|::...|:.:.....:..|::.|..|.....::.....::||
Mouse   119 SISKDDEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAKKGKPVTMKDVLGAYSMDV 183

  Fly   182 ICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTL--KTL 243
            |..|:.||:::::.|.....|:..|.:   ::...|.|...:..||.| .|.|...:..:  |..
Mouse   184 ITSTSFGVNVDSLNNPEDPFVEKAKKL---LRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDS 245

  Fly   244 QDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSS------KVDGRPLTSQELYEEVS 302
            .:|..:.:.:..|.|         .|...:.::.||..:::|      ||..:.|:..|:..:..
Mouse   246 IEFFKKFVDRMKESR---------LDSKQKHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSI 301

  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367
            .|:|.|::||:|.:.|.::.|:.|||.|:||.:|..:.:....   ..|:..:..|::||:.:.|
Mouse   302 IFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNKA---PPTYDTVMEMEYLDMVLNE 363

  Fly   368 AQRLYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDREKPG-- 430
            ..||||....:.|..:||..::|..:|||:|:.:....|.::.:.:.:|.:||||||.:|..|
Mouse   364 TLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSI 428

  Fly   431 -PFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELV----SKDGYISTTLGLQPA 490
             |:.|:||..|||||:|.:|||:.:|..::||::||...|..:..:    |:.|.      |||
Mouse   429 DPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGL------LQP- 486

  Fly   491 EKK------SRDA 497
            ||.      .|||
Mouse   487 EKPIVLKVVPRDA 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	117/457 (26%)
Cyp3a11	NP_031844.1	CYP3A	67..493	CDD:410743	116/452 (26%)