Protein Alignment Cyp4e1 and Cyp19a1

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_031836.1
• Gene: Cyp19a1 / 13075
• MGIID: 88587
• Length: 503
• Species: Mus musculus
• Alignment Length: 527
• Identity: 129/527 - (24%)
• Similarity: 216/527 - (40%)
• Gaps: 103/527 - (19%)

  Fly    10 ALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWWHEYGKDNFRYW 74
            |:||.|:    :|||   .::...:..|.:|  |..:.:|..|.....||.             |
Mouse    25 AMPLLLI----MGLL---LLIWNCESSSSIP--GPGYCLGIGPLISHGRFL-------------W 67

  Fly    75 IGYYSNIMVTNPKYMEF----ILSSQTL-ISKSDVYDLTHPWLGLGLLTSTGSK----------- 123
            :|..|.....|..|.||    |...:|| ||||.  .:.|.......::..|||
Mouse    68 MGIGSACNYYNKMYGEFMRVWISGEETLIISKSS--SMFHVMKHSHYISRFGSKRGLQCIGMHEN 130

  Fly   124 ----------WHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLT 178
                      |...|.....|.....|....||..|:..:.:|:|.:|.|.....|......::.
Mouse   131 GIIFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIM 195

  Fly   179 LDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWK----RNKYLFHFAPEYPEYSKT 239
            ||......:|:.::     .|::|:..:..        |:.|:    :....|..:..|.:|.::
Mouse   196 LDTSNMLFLGIPLD-----ESAIVKKIQGY--------FNAWQALLIKPNIFFKISWLYRKYERS 247

  Fly   240 LKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTF 304
            :|.|:|    .||..:|.::..:....|.::.    |.|...|:.::..| .||.:.:.:.:...
Mouse   248 VKDLKD----EIAVLVEKKRHKVSTAEKLEDC----MDFATDLIFAERRG-DLTKENVNQCILEM 303

  Fly   305 MFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQ 369
            :....||.:..:.|.:.|::.:|:.:..:..|...|:|    .||...::|..:|.::.||.|:.
Mouse   304 LIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVG----DRDIKIEDIQNLKVVENFINESM 364

  Fly   370 RLYPSVPFIGRFTEKDYVIDGDIVPKGTT--LNLGLL-MLGYNDRVFKDPHKFQPERFDREKPGP 431
            |..|.|..:.|...:|.||||..|.|||.  ||:|.: .|.|    |..|::|..|.|  ||..|
Mouse   365 RYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEY----FPKPNEFTLENF--EKNVP 423

  Fly   432 FEYV-PFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLP----ALDELVSKDGYISTTLGLQPAE 491
            :.|. ||..|||.|.|:..|::.:|.|:..::|.|:|..    .::.:..|:     .|.|.|.|
Mouse   424 YRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQVKTLQKRCIENIPKKN-----DLSLHPNE 483

  Fly   492 KKSRDAH 498
                |.|
Mouse   484 ----DRH 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	115/469 (25%)
Cyp19a1	NP_031836.1	CYP19A1	72..485	CDD:410709	111/455 (24%)