DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp4e1 and CYP4F22

DIOPT Version :9

Sequence 1:NP_524771.1 Gene:Cyp4e1 / 44632 FlyBaseID:FBgn0015034 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_775754.2 Gene:CYP4F22 / 126410 HGNCID:26820 Length:531 Species:Homo sapiens


Alignment Length:558 Identity:162/558 - (29%)
Similarity:260/558 - (46%) Gaps:96/558 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 AFLALPLFLVTYFELGLLRRKRMLNKF-----------QGPSMLPLVGNAHQMGNTPTE------ 54
            |...|.|||:.:....|||..|:...|           |.|....|:|  |.....|.|      
Human    23 AVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLG--HLGMYLPNEAGLQDE 85

  Fly    55 --ILNRFFGWWHEYGKDNFRY----WIGYYSNIMV-TNPKYMEFILSSQTLISKSD--VYDLTHP 110
              :|            ||..:    |:|....::| .:|.|::.:|.:...|:..|  .|....|
Human    86 KKVL------------DNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKP 138

  Fly   111 WLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNI-FDFQEEA 174
            |||.|||.|.|.||.:||:::||||||:||:.:.::.|:::.....:.:.:|:|..: .|..|..
Human   139 WLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHI 203

  Fly   175 HYLTLDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEY--- 236
            ..:|||.:.......:.|..|..|..       |:..|::.|.|  .|.:|..|...::..|   
Human   204 SLMTLDSLQKCVFSYNSNCQEKMSDY-------ISAIIELSALS--VRRQYRLHHYLDFIYYRSA 259

  Fly   237 -----SKTLKTLQDFTNEII-AKRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-VDGRPLTS 294
                 .:....:..||.|:| .:|..:|:.|.|..:||.:  .|.:.|:|.||.:: .||:.|:.
Human   260 DGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQ--GKTLDFIDVLLLARDEDGKELSD 322

  Fly   295 QELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMK 359
            :::..|..||||||||||:||:.:.::.|:::|:.|||...|..:||....| .:..:.:::.:.
Human   323 EDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGREL-EELEWDDLTQLP 386

  Fly   360 HLDLFIKEAQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPER 423
            ...:.|||:.|.||.|..:.|...:|..: ||.|:|||....:.:....:|..|:.|...:.|.|
Human   387 FTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYR 451

  Fly   424 FDREKP---GPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTL 485
            ||.:.|   .|..||||||||||||||.||:.|::.||:..:..|.                  |
Human   452 FDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFR------------------L 498

  Fly   486 GLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMK 523
            .:....|..|           ...:.|::||||.|:::
Human   499 SVDRTRKVRR-----------KPELILRTENGLWLKVE 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp4e1NP_524771.1 p450 34..469 CDD:278495 143/464 (31%)
CYP4F22NP_775754.2 p450 60..524 CDD:278495 152/518 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154636
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3B9GY
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1247045at2759
OrthoFinder 1 1.000 - - FOG0000016
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X23
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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