Protein Alignment Cyp4e1 and CYP4F8

DIOPT Version :10

• Sequence 1: NP_524771.1
• Gene: Cyp4e1 / 44632
• FlyBaseID: FBgn0015034
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 154/550 - (28%)
• Similarity: 272/550 - (49%)
• Gaps: 79/550 - (14%)

  Fly     2 WIVL----CAFLALPLFLVTYF------ELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTE-- 54
            |::|    .::|...:...||.      .|....:.|..|.|.|  .|.||        ||||
Human    19 WLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLG--HLGLV--------TPTEEG 73

  Fly    55 --ILNRFFGWWHEYGKDNFRYWIGYYSNIM-VTNPKYMEFILSSQTLISKSDV--YDLTHPWLGL 114
              :|.:....:.:    .|..|:|..:.|: :.:|..:..::::...|:..|:  |....||||.
Human    74 LRVLTQLVATYPQ----GFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGD 134

  Fly   115 GLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVA-DGGNIFDFQEEAHYLT 178
            |||.|.|.||..||:::|||||||||:.:.::.::::.....:.:::| :|....|..|....:|
Human   135 GLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMT 199

  Fly   179 LDVICDTAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTL 243
            ||.:.........|..| :.|..:.|..:::..:..|....::...:|:...|....:.:..:.:
Human   200 LDSLQKCIFSFDSNCQE-KPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLV 263

  Fly   244 QDFTNEIIAKRIEVRKSGLEVGIKADEF-----SRKKMAFLDT-LLSSKVDGRPLTSQELYEEVS 302
            .|||:.:|.:|   |::....|:  |:|     ..|.:.|:|. |||...:|:.|:.:::..|..
Human   264 HDFTDAVIQER---RRTLTSQGV--DDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEAD 323

  Fly   303 TFMFEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKE 367
            ||||.|||||.||:.:.:|.|:|||:.||:...|..::: .....::..:.:::.:..|.:.:||
Human   324 TFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELL-KDREPKEIEWDDLAQLPFLTMCLKE 387

  Fly   368 AQRLYPSVPFIGRFTEKDYVI-DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDRE---K 428
            :.||:|.:|...|...:|.|: |..::|||...|:.:..:.:|..|:.||..:.|.|||.|   |
Human   388 SLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQK 452

  Fly   429 PGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKK 493
            ..|..::|||||||||||||||:.|:|.|::..:..|.:||
Human   453 RSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILP------------------------ 493

  Fly   494 SRDAHNHKYDPILSASMTLKSENGLHLRMK 523
                 :|: :|..:..:.|::|:||.||::
Human   494 -----DHR-EPRRTPEIVLRAEDGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	CYP4	68..520	CDD:410721	134/465 (29%)
CYP4F8	NP_009184.1	CYP4F	74..515	CDD:410772	135/481 (28%)