DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e1 and CYP46A1

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_006659.1	Gene:	CYP46A1 / 10858	HGNCID:	2641	Length:	500	Species:	Homo sapiens

Alignment Length:	495	Identity:	137/495 - (27%)
Similarity:	223/495 - (45%)	Gaps:	79/495 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PSMLPLVGNAHQMGNTP-----TEILNR-----FFGWWHEYGKDNFRYWIGYYSNIMVTNPKYME 90
            ||.|        :|:.|     .|:..|     |..|..:|| ...|..:.:.::::||:|:.::
Human    39 PSFL--------LGHLPCFWKKDEVGGRVLQDVFLDWAKKYG-PVVRVNVFHKTSVIVTSPESVK 94

  Fly    91 FILSSQTLISKSDVYDLTHP-----WLGLGLLTSTG-SKWHKHRKMITPAFHFNILQDFHEVMNE 149
            ..|.|......|.:|.....     ..|.||::... .:|||.|::|..||..:.|....|..||
Human    95 KFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNE 159

  Fly   150 NSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVS----INAMENRSSSVVQAFKDITY 210
            .:.:.::.|:..|||......|:...|..:|::...|.|:.    :.|.:..|.:|....:.||.
Human   160 KAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITA 224

  Fly   211 TIKMRA-FSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVG-------IK 267
            :....| |.|.||.        :..|..::::.|:....:.:.:|.|..|.|.||.       :|
Human   225 SRNTLAKFLPGKRK--------QLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK 281

  Fly   268 ADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEK 332
            |:|.::.....||..:                   ||...||:|:.:.:.|.|..|||.|:...:
Human   282 AEEGAQDDEGLLDNFV-------------------TFFIAGHETSANHLAFTVMELSRQPEIVAR 327

  Fly   333 LFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGT 397
            |..|..:|:|:.   |...|:::..:::|...:||:.||||......|..|::.:|||..||..|
Human   328 LQAEVDEVIGSK---RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNT 389

  Fly   398 TLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGP-FEYVPFSAGPRNCIGQKFALLEIKTVVSKI 461
            .|.....::|..|..|:||..|.|:||....|.| |.|.|||.|.|:||||:||.:|:|.|::|:
Human   390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454

  Fly   462 IR--NFEVLP----ALDE---LVSKDGYIST--TLGLQPA 490
            ::  .|.::|    .|.|   |...|..:.|  ..|.|||
Human   455 LQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPA 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	127/463 (27%)
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	128/465 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810