DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e1 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	551	Identity:	146/551 - (26%)
Similarity:	262/551 - (47%)	Gaps:	91/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLP-LVGNAHQMGNTPTEILNRFFGWWHEYG 67
            :|||       |||    .::..:|.|..|..|.:.. ::|:...||:. .|.|.|......:||
Zfish    18 LLCA-------LVT----RIIINRRALRCFNQPPLRNWIMGHMGLMGHN-EEGLQRVDDLVCKYG 70

  Fly    68 KDNFRYWIG-YYSNIMVTNPKYMEFILSSQTLISKSD--VYDLTHPWLGLGLLTSTGSKWHKHRK 129
             .:..:::| :|:.:.:.:|.|:..:|::...|:..|  .|....||||..||..:|.:|.:||:
Zfish    71 -HSCSWFLGPFYNMVRLFHPDYIRSLLTASASITLKDRIFYGFMKPWLGNCLLLQSGQEWSRHRR 134

  Fly   130 MITPAFHFNILQDFHEVMNENSTKFIDQLKK-VADGGNIFDFQEEAHYLTLDVI------CDTAM 187
            ::||||||:||:.:..:.|:::....|:.:: :|.|.:..|..|:...||||.:      |||
Zfish   135 LLTPAFHFDILKKYVHIFNQSTNIMHDEWRRLLAKGEHSVDMFEQISSLTLDSLLKCTFSCDT-- 197

  Fly   188 GVSINAMENRSSSVVQAFKDITYTIKMRA-FSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEII 251
                 ..:.:....:.|..|::..:..|. :.|:..: :|:..:.:...:.:....:..||.:|:
Zfish   198 -----HSQEKPRQYISAILDLSRLLVQRQHYLPYHWD-WLYWRSAQGRRFQQACAVVHQFTADIV 256

  Fly   252 AKRIEVRKSGLEVGIKADEFS----------RKKMAFLDTLLSSKVD-GRPLTSQELYEEVSTFM 305
            .:|      ..::..::|..|          ||....:|.||.:|.| |..||::|:......||
Zfish   257 QER------RTQLDQQSDPESHPENTGRYRKRKNTDLIDLLLLAKDDKGEGLTNEEIKAHADMFM 315

  Fly   306 FEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDA---TFQEISTMKHLDLFIKE 367
            |.|||||.|.:.:..|.|:.:.|.||:...|..|::.    .||.   .::::|.:....:.|||
Zfish   316 FAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDLLA----DRDTHTIGWEDLSQLTFTTMCIKE 376

  Fly   368 AQRLYPSVPFIGRFTEKDYVIDGD-IVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFD---REK 428
            :.||:..|..:.|:..::....|| ::|.|....:.:..:..|.:|:.||..|.|.|||   .:.
Zfish   377 SLRLHSPVLALTRYYSQNMKTPGDCVIPHGCLCLISIYGVHRNPQVWPDPLVFDPTRFDPHNSDS 441

  Fly   429 PGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKK 493
            ..|..::||||||||||||.||:.|:|.||:..:..|::||                |.:|..:.
Zfish   442 RSPHAFIPFSAGPRNCIGQNFAMAEMKVVVALTLARFKILP----------------GPKPVRRL 490

  Fly   494 SRDAHNHKYDPILSASMTLKSENGLHLRMKQ 524
            .:              :.|::|.|:.|..::
Zfish   491 YQ--------------LVLRAEGGMILHFQE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	129/464 (28%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	136/514 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010