DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14630 and BBOX1

DIOPT Version :9

Sequence 1:	NP_651985.1	Gene:	CG14630 / 44620	FlyBaseID:	FBgn0014903	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001363187.1	Gene:	BBOX1 / 8424	HGNCID:	964	Length:	387	Species:	Homo sapiens

Alignment Length:	374	Identity:	135/374 - (36%)
Similarity:	203/374 - (54%)	Gaps:	23/374 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EEQGNLLKYPQVWLRDNCQCAECFHAATRARKSHWDRGPLNIPVSQVAYNKERKQLEIIWQDKHR 98
            :|:.:|  ||.|||||||.|::|:..:.:|||...:...:||.:..:.:  :||::.|.|.|:|.
Human    23 DEEESL--YPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIF--DRKKVYITWPDEHY 83

  Fly    99 STFDLGWLRERDFGETGRKHYLEEVYKPPAQLWGKTEFEDVKREFQ-----YEDVLEQDAALRVW 158
            |.|...||::|.|.:..|.....|::.|..|.||.        |.|     :||||..|.....|
Human    84 SEFQADWLKKRCFSKQARAKLQRELFFPECQYWGS--------ELQLPTLDFEDVLRYDEHAYKW 140

  Fly   159 LEALAVQGFAILKGAPNDINVAKKLAERIGYIKRTTYGDVFEVKSKPNARNYAYLMTPLPLHTDM 223
            |..|...|...|.||.:......||.:|:|::..|.||..::|:.|.:|.|.||....|..|||.
Human   141 LSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDY 205

  Fly   224 PYYEYKAGINILHTLVQSESKGGANTLTDGFNVASQLQKLHPEDFEVLKSVPVNWFDIGHDGDDS 288
            |...:..|:.:||.:.|:.: ||.:.:.|||||..:|:|.:|:.|::|.|..|::.|||.|..|
Human   206 PALHHPPGVQLLHCIKQTVT-GGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCD- 268

  Fly   289 KPFHSLWRAPVICLDVDGRFARINQNTTKRDSRFSVSLAQAVSWYKAYDKFLEIAQSEAVE--FK 351
              |....:..:|.||..|:..|||.|...||:.|.|.:.:...:|.|..:|:::..|:..:  ||
Human   269 --FSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFK 331

  Fly   352 TQAGDVFVFNNLRMLHGRTAYEDAPGNKRHLVGAYVDWDIIYSKLRTLK 400
            ...|||..|:|.|:||||.:||......|||.|||.|||::.|:||.|:
Human   332 MNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILR 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14630	NP_651985.1	carnitine_bodg	30..400	CDD:274118	134/372 (36%)
		DUF971	<41..107	CDD:294847	25/65 (38%)
		CAS_like	120..390	CDD:238154	98/276 (36%)
BBOX1	NP_001363187.1	carnitine_bodg	16..381	CDD:274118	135/374 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152943
Domainoid	1	1.000	167	1.000	Domainoid score	I3861
eggNOG	1	0.900	-	-		E1_COG2175
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3116
Isobase	1	0.950	-	0.909372	Normalized mean entropy	S3503
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D534559at33208
OrthoFinder	1	1.000	-	-		FOG0003526
OrthoInspector	1	1.000	-	-		otm41552
orthoMCL	1	0.900	-	-		OOG6_102379
Panther	1	1.100	-	-	O	PTHR10696
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2023
SonicParanoid	1	1.000	-	-		X2892
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.740