DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14630 and tmlhe

DIOPT Version :9

Sequence 1:	NP_651985.1	Gene:	CG14630 / 44620	FlyBaseID:	FBgn0014903	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_682831.3	Gene:	tmlhe / 555271	ZFINID:	ZDB-GENE-091204-144	Length:	410	Species:	Danio rerio

Alignment Length:	383	Identity:	99/383 - (25%)
Similarity:	173/383 - (45%)	Gaps:	26/383 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RLCPDYVEVQEEQGNLLKYPQVWLRDNCQCAECFHAATRARKSHWDRGPLNIPVSQVAYNKERKQ 88
            :|.||.:|: ...|.::.:..|||||:|:.|.|:::.|..|  :.|...:::.:.......:...
Zfish    43 QLLPDCLEL-NYGGLVMHFDYVWLRDHCRSASCYNSKTNQR--NLDTASIDLTIRPSKSRVDEHN 104

  Fly    89 LEIIWQDKHRSTFDLGWLRERDFGETGRKHYLEEVYKPPAQLWGKTEFEDVK-REFQYEDVLEQD 152
            |.:.|.|.|.:.::|.||.:..: |...:..::     |..||....:...| ....::..:..|
Zfish   105 LFLTWPDGHVTRYNLAWLAQNSY-EGQMRSAIQ-----PRILWNAHIYSSAKVPAANWDKFMSCD 163

  Fly   153 AALRVWLEALAVQGFAILKGAPNDINVAKKLAERIGYIKRTTYGDVFEVKSKPNARNYAYLMTPL 217
            ..|:.:|....:.|.|.::|.|..:...:.:.:|:..|:.|.||.::...|..:..:.||....|
Zfish   164 EELKNFLNNFLLYGIAFVEGVPPTLEATETVTQRVSLIRETIYGRMWNFTSDFSRGDTAYTKLAL 228

  Fly   218 PLHTDMPYYEYKAGINILHTLVQSESKGGANTLTDGFNVASQLQKLHPEDFEVLKSVPVNWFDIG 282
            ..|||..|::...||.:.|.| :.|..||...|.|||:.|..:.:..||:|::|..||:....:.
Zfish   229 DRHTDTSYFQEPCGIQVFHCL-RHEGTGGRTLLVDGFHAADTVLQQTPENFQLLSHVPIKHDYVE 292

  Fly   283 HDGDDSKPFHSLWRAPVICLDV---DGRFARINQNTTKRDSRFSVSLAQAVSWYKAYDKF---LE 341
            :..|...  |.:...||  |:|   :.....|..|...|....:|.......||.|:.|.   |.
Zfish   293 NLSDHRN--HMIGIGPV--LNVYPWNNEVYMIRYNNYDRSVINTVPHDVVRRWYVAHRKLTAELR 353

  Fly   342 IAQSEAVEFKTQAGDVFVFNNLRMLHGRTAYEDAPGNKRHLVGAYVDWDIIYSKLRTL 399
            .|.:| :..|.:.|.|...:|.|:||||.::.    ..|.|.|.|:..|.:.:..|:|
Zfish   354 RADNE-LWVKLKPGKVLFVDNWRVLHGRESFT----GLRQLCGCYLTRDDVLNTARSL 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14630	NP_651985.1	carnitine_bodg	30..400	CDD:274118	96/377 (25%)
		DUF971	<41..107	CDD:294847	17/65 (26%)
		CAS_like	120..390	CDD:238154	72/276 (26%)
tmlhe	XP_682831.3	DUF971	49..122	CDD:294847	18/75 (24%)
		carnitine_TMLD	60..408	CDD:274119	94/365 (26%)
		CAS_like	132..397	CDD:238154	72/279 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D534559at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2023
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950