DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14630 and CG4335

DIOPT Version :9

Sequence 1:	NP_651985.1	Gene:	CG14630 / 44620	FlyBaseID:	FBgn0014903	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_650886.1	Gene:	CG4335 / 42421	FlyBaseID:	FBgn0038795	Length:	364	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	100/381 - (26%)
Similarity:	168/381 - (44%)	Gaps:	43/381 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LLKYP---------QVWLRDNCQCAECFHAATRARKSHWDRGPLNIPVSQVAYNKERKQLEIIWQ 94
            |||:|         :.||||:|:|.||.:..|..|:......|.:|....|.|  :...|::.|.
  Fly     3 LLKHPKTSQSIEINEFWLRDHCRCVECLNFETNQRRYDVLDLPADIMPLDVKY--DGMNLQVQWS 65

  Fly    95 DKHRSTFDLGWL----RERDFGETGRKHYLEEVYKPPAQLWGKTEFEDVKR--EFQYEDVLEQDA 153
            |.|:|.:||.::    .||..|...:...|..        |.::.....:|  .|....::..|.
  Fly    66 DAHKSNYDLDFIFDSQLERLIGRRSKSTNLTP--------WNRSIILQNERHLRFPLPQLVSSDN 122

  Fly   154 ALRVWLEALAVQGFAILKGAPNDINVAKKLAERIGYIKRTTYGDVFEVKSKPNARNYAYLMTPLP 218
            .:|..:|:|...|...:.......|:.:....|:..:.:|.:|:::.....|:..:.||....|.
  Fly   123 EVRSLVESLVRYGIVFIDDVAPTANMTELALRRVFPLMKTFFGEMWTFSDNPDHADTAYTKLYLG 187

  Fly   219 LHTDMPYYEYKAGINILHTLVQSESKGGANTLTDGFNVASQLQKLHPEDFEVLKS--VPVNWFDI 281
            .|||..|:...||:..||.:..|.| ||.|...||.:|..:|::.:|..::||.|  ||..:.:.
  Fly   188 SHTDNTYFCDAAGLQALHCIEHSGS-GGENFFVDGLHVVHELKRRYPAAYDVLCSVQVPGEYIEK 251

  Fly   282 GHDGDDSKPFHSLWRAPVICLD-VDGRFARINQNTTKRDSRFSVSLAQAVSWYKAYDKFLEIAQS 345
            |.        |....||:|.:| :...|.::..|...|....::..|:...:|.:..:.|.|.:.
  Fly   252 GE--------HHYHTAPIIQVDPLTQEFVQLRLNVYDRAVFNTIPQAEMAEFYDSLRQLLLIVRD 308

  Fly   346 EAVEF--KTQAGDVFVFNNLRMLHGRTAYEDAPGNKRHLVGAYVDWDIIYSKLRTL 399
            :..::  |...|.:.:|:|.|:||||.||.    ..|.:.|:||......||.|.|
  Fly   309 KQQQWALKLCPGSIVLFDNWRVLHGREAYT----GSRTMSGSYVQRTDFLSKARVL 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14630	NP_651985.1	carnitine_bodg	30..400	CDD:274118	100/381 (26%)
		DUF971	<41..107	CDD:294847	23/78 (29%)
		CAS_like	120..390	CDD:238154	68/276 (25%)
CG4335	NP_650886.1	carnitine_TMLD	19..361	CDD:274119	96/365 (26%)
		DUF971	<19..70	CDD:294847	18/52 (35%)
		CAS_like	110..350	CDD:294121	65/252 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457822
Domainoid	1	1.000	69	1.000	Domainoid score	I2287
eggNOG	1	0.900	-	-		E1_COG2175
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I1572
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52475
OrthoDB	1	1.010	-	-		D534559at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46559
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10696
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2023
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.940